PHARYNGEAL AND UPPER ESOPHAGEAL SPHINCTER MANOMETRY IN HUMANS
PHARYNGEAL AND UPPER ESOPHAGEAL SPHINCTER MANOMETRY IN HUMANS
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DOI：
10.1152/ajpgi.1990.258.2.g173
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发表时间：
1990-02-01
影响因子：
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通讯作者：
CASTELL, DO
中科院分区：
文献类型：
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作者：
CASTELL, JA;DALTON, CB;CASTELL, DO
吞咽过程中咽-食管上括约肌（UES）协调的测压研究已被证明是困难的。UES的不对称性使得使用单个未定向的传感器进行压力测量变得可疑。灌注系统缺乏测量咽部收缩压力峰值的必要响应率。由于压力变化迅速，难以精确量化吞咽期间咽部收缩和UES舒张的协调。我们测试了测量超过360 °的压力的改进的固态换能器。将该探头放置在近端UES中，近端5 cm处放置第二个单一探头。用Apple IIe微型计算机收集和分析数据。开发了一个计算机程序来测量9个时序、UES静息压、UES舒张最低点和咽部收缩压。我们对21名志愿者进行了研究，他们分别吞咽了6次干水、5毫升水、10毫升水和20毫升水。干咽与湿咽（5 ml）差异显著（P < 0.05）。所有定时序列随着大剂量的增加而逐渐变长。剩余压力不变。还测量了7名志愿者使用Dent套管和UES中的单个灌注孔进行湿吞咽（5 ml）和干吞咽的时间序列;未观察到差异。
Manometric studies of pharyngeal-upper esophageal sphincter (UES) coordination during swallowing have proven difficult. Asymmetry of the UES makes pressure measurements with a single, unoriented transducer suspect. Perfused systems lack the necessary response rate for measuring peak pharyngeal contraction pressures. Precise quantification of the coordination of pharyngeal contractions and UES relaxations during swallowing is difficult because of rapid pressure changes. We tested a modified solid-state transducer that measures pressures over 360.degree.. This transducer was placed in the proximal UES with a second, single transducer 5 cm proximal. Data were collected and analyzed with an Apple IIe microcomputer. A computer program was developed to measure nine timing sequences, UES resting pressure, nadir of UES relaxation, and pharyngeal contraction pressures. We studied 21 volunteers with six swallows each for dry, 5, 10, and 20 ml of water. Dry swallows differed significantly (P < 0.05) from wet (5 ml). All timing sequences became progressively longer with increasing bolus size. Residual pressures were unchanged. Timing sequences were also measured for wet (5 ml) and dry swallows in seven volunteers using a Dent sleeve and single perfused orifice in the UES; no differences were seen.