Are the imaging features of the pleomorphic variant of invasive lobular carcinoma different from classic ILC of the breast?
Are the imaging features of the pleomorphic variant of invasive lobular carcinoma different from classic ILC of the breast?
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DOI：
10.1016/j.breast.2012.07.016
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发表时间：
2013-06-01
期刊：
影响因子：
3.9
通讯作者：
Cho, Eun Yoon
中科院分区：
文献类型：
--
作者：
Jung, Hye Na;Shin, Jung Hee;Cho, Eun Yoon
本研究的目的是评估多形性浸润性小叶癌 (PILC) 在放射学和临床病理学特征方面是否与经典浸润性小叶癌 (CILC) 不同。我们比较了 2004 年至 2009 年 21 名患者的 22 例经手术证实的 PILC 和来自 47 名连续患者的 47 例 CILC 的放射学和临床病理学特征。对于所有病例，我们回顾了影像学表现、病历和病理结果。与 CILC 相比，PILC 具有更高的 T 分期、N 分期、核分级和组织学分级。与 CILC 相比，PILC 更常见雌激素受体阴性和 HER2 阳性（所有 p < 0.05）。然而，两组之间的年龄、症状、肿瘤大小、广泛的导管内成分、淋巴血管侵犯、三阴性特征或多重性没有显着差异。 22 例中的 1 例（4.5%）在乳房 X 光检查中未检测到 PILC，而 47 例中的 7 例（14.9%）在乳房 X 光检查中未检测到 CILC，在 40 例中的 2 例（5.0%）中 MRI 中未检测到 CILC（分别为 p = 0.42 和 p = 1.000）。对于 PILC 和 CILC，MRI 比乳房 X 光检查发现更常见的多重性 (p < 0.001)，但与 US 相似 (p = 0.066)。大多数病变在乳房 X 光检查和超声检查中显示出针状肿块或结构扭曲，伴或不伴钙化。两组之间在 MRI 上未观察到肿块和/或非肿块病变或动力学差异。PILC 显示出更多的病理侵袭性特征，但无法根据影像学结果与 CILC 区分开。 (C) 2012 Elsevier Ltd. 保留所有权利。
The aim of this study was to evaluate whether pleomorphic invasive lobular carcinoma (PILC) is different from classic invasive lobular carcinoma (CILC) in terms of radiologic and clinicopathologic features.We compared the radiologic and clinicopathologic features of 22 surgically confirmed PILCs in 21 patients from 2004 to 2009 and 47 CILCs from 47 consecutive patients. For all cases, we reviewed the imaging findings, medical records and pathological results.PILC had a higher T stage, N stage, nuclear and histologic grade compared to CILC. PILC was more commonly negative for estrogen receptors and positive for HER2 than CILC (all p < 0.05). However, there were no significant differences in age, symptoms, tumor size, extensive intraductal component, lymphovascular invasion, triple negative profile, or multiplicity between the two groups. PILC was not detected on mammography in 1 (4.5%) of 22 cases, whereas CILC was not detected on mammography in 7 (14.9%) of 47 cases and on MRI in 2 (5.0%) of 40 (p = 0.42 and p = 1.000, respectively). MRI identified more frequent multiplicity than mammography for both PILC and CILC (p < 0.001), but was similar to US (p = 0.066). Most lesions showed a spiculated mass or architectural distortion with or without calcifications on mammography and ultrasound. No differences in mass and/or non-mass lesions or kinetics on MRI were observed between the two groups.PILC shows more pathologically aggressive features, but cannot be differentiated from CILC based on imaging findings. (C) 2012 Elsevier Ltd. All rights reserved.