Chemoprevention of melanoma.
Chemoprevention of melanoma.
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DOI：
10.1016/b978-0-12-397927-8.00012-9
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Robertson, Gavin P
中科院分区：
文献类型：
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作者：
Madhunapantula, Subbarao V;Robertson, Gavin P
尽管药物发现计划和分子方法在确定药物靶点方面取得了进展，但黑色素瘤的发病率和死亡率仍以惊人的速度上升。现有的预防策略通常包括痣筛查，然后手术切除良性痣和异常痣。然而，由于缺乏有效的筛查和手术切除后疾病复发的方案，需要更好的化学预防剂。尽管防晒霜已被广泛用于预防紫外线诱导的皮肤癌，但基于人群的相关研究的结果存在争议，需要进一步验证才能最终确认防晒霜的化学保护功效。某些研究表明，使用防晒霜的人患皮肤癌的几率会增加。因此，迫切需要有效的化学预防剂来预防黑色素瘤。这本书的章节，回顾了目前的理解，关于黑色素瘤的化学预防和各种策略，用于实现这一目标。
Despite advances in drug discovery programs and molecular approaches for identifying the drug targets, incidence and mortality rates due to melanoma continues to rise at an alarming rate. Existing preventive strategies generally involve mole screening followed by surgical removal of the benign nevi and abnormal moles. However, due to lack of effective programs for screening and disease recurrence after surgical resection there is a need for better chemopreventive agents. Although sunscreens have been used extensively for protecting from UV-induced skin cancer, results of correlative population based studies are controversial, requiring further authentication to conclusively confirm the chemoprotective efficacy of sunscreens. Certain studies suggest increased skin-cancer rates in sunscreen users. Therefore, effective chemopreventive agents for preventing melanoma are urgently required. This book-chapter, reviews the current understanding regarding melanoma chemoprevention and the various strategies used to accomplish this objective.