Mathematical modelling of the oxytocin and vasopressin secretory system.
Mathematical modelling of the oxytocin and vasopressin secretory system.
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DOI：
10.1016/j.coemr.2022.100341
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发表时间：
2022-06
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下丘脑的大细胞催产素和加压素神经元投射到垂体后叶，在那里它们将其肽激素信号直接分泌到血液中。它们在解剖学上不同的大型分泌机制提供了一个独特的可访问系统，在此系统中，可以结合实验和建模方法来研究输入信号和神经元的电生理特性与生理功能的关系。我们描述了这些机制如何被翻译和组装成一个数学模型表示，可以解释和模拟这些神经元的复杂和高度非线性的刺激-分泌耦合，以及这个模型如何被应用于进一步理解这些系统。
Magnocellular oxytocin and vasopressin neurons of the hypothalamus project to the posterior pituitary where they secrete their peptide hormone signals directly into the bloodstream. Their large anatomically distinct secretory mechanisms provide a uniquely accessible system in which to unite experimental and modelling approaches in the investigation of how input signals and electrophysiological properties of neurons relate to physiological function. We describe how the mechanisms have been translated and assembled into a mathematical model representation that can explain and simulate the complex and highly non-linear stimulus-secretion coupling of these neurons, and how this model has been applied to further understand these systems.