Preparation of porous composite implant materials by in situ polymerization of porous apatite containing ε-caprolactone or methyl methacrylate
Preparation of porous composite implant materials by in situ polymerization of porous apatite containing ε-caprolactone or methyl methacrylate
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DOI：
10.1016/s0142-9612(00)00268-4
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发表时间：
2001-06
期刊：
影响因子：
14
通讯作者：
D. Walsh;T. Furuzono;J. Tanaka
中科院分区：
文献类型：
--
作者：
D. Walsh;T. Furuzono;J. Tanaka
以多孔磷灰石水泥为基体，采用超高真空技术制备了生物可降解、生物稳定的复合泡沫材料。对于CL复合材料，使用微量水作为引发剂并在120°C下加热最多10天或在80°C下加热60天来诱导原位聚合。MMA复合材料使用AIBN引发剂在70°C下聚合8小时。CL制备得到的复合材料的聚己内酯（PCL）数均分子量（Mn）在10天后最大为7.1× 103 g/mol，在60天后最大为16.8× 103 g/mol。PCL和PMMA含量分别接近50和40wt%，聚合物作为磷灰石晶体板上的薄涂层存在，并且均匀地分布在整个样品中。在制备过程中用单体饱和的磷灰石的再抽空确保了磷灰石水泥内的200 nm以上的微通道基本上不含聚合物，并且部分保留了磷灰石泡沫的整体大孔结构。PCL和PMMA复合材料的最大压缩强度分别从9 MPa增加到37和64 MPa。PCL复合材料的水滴接触角为64°，因此适合于细胞附着。PMMA复合材料表面更疏水。复合材料经受电晕放电以在表面处诱导合适的适度亲水性。
Biodegradable and biostable composite foams were formed from porous apatite cement infiltrated with ε-caprolactone (CL) or methylmethacrylate (MMA) using a high over vacuum. For CL composites in situ polymerization was induced using trace water as an initiator and heating at 120°C for up to 10 days or at 80°C for 60 days. MMA composites were polymerized using AIBN initiator at 70°C for 8h. CL preparations gave composites with a polycaprolactone (PCL) number average of molecular weight (Mn) up to the maximum of 7.1×103g/mol after 10 days and 16.8×103g/mol after 60 days. The PCL and PMMA contents were close to 50 and 40wt%, respectively, polymer was present as a thin coating on the apatite crystal plates and was evenly distributed throughout the samples. Re-evacuation of apatite saturated with monomer during preparation ensured that the upwards of 200nm microchannels within the apatite cement were largely free of polymer, and the overall macroporous structure of the apatite foams was partly retained. Maximum compressive strengths increased from 9MPa to 37 and 64MPa for PCL and PMMA composites, respectively. The water drop contact angle of the PCL composite was 64°, and therefore suitable for cell attachment. PMMA composite surfaces were more hydrophobic. Composites were subjected to corona discharge to induce suitable moderate hydrophilicity at the surface.