Optical chemical sensors based on sol-gel materials: Recent advances and critical issues
Optical chemical sensors based on sol-gel materials: Recent advances and critical issues
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DOI：
10.1007/bf02436983
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发表时间：
1997-01-01
影响因子：
2.5
通讯作者：
Murphy, V
中科院分区：
文献类型：
--
作者：
MacCraith, BD;McDonagh, C;Murphy, V
利用溶胶-凝胶法制备光学化学传感器和生物传感器材料引起了人们的极大兴趣。这种兴趣主要来自于Sol-Gel工艺的设计灵活性和制造的简单性。在大多数应用中，溶胶-凝胶材料用于提供微孔支撑基质，分析物敏感物种被包裹在其中，较小的分析物分子可能扩散到其中。基于包埋的有机和无机染料、酶和其他生物分子的传感器已有报道。已经采用了一系列传感器配置，包括整体、薄膜以及更精细的结构。本文介绍了使用溶胶-凝胶衍生材料的光学化学传感器的最新重大发展。这些发展包括为优化传感器响应而量身定做的溶胶-凝胶材料、先进的波导结构和新颖的探针式传感器。这些问题仍然是关键的最终部署的溶胶-凝胶传感器进行了审查。特别是，讨论了浸出、微观结构稳定性、扩散限制的响应时间和对干扰的敏感性等问题，并提出了一些解决方案。
The use of the sol-gel process to produce materials for optical chemical sensors and biosensors is attracting considerable interest. This interest derives mainly from the design flexibility of the sol-gel process and the ease of fabrication. In most applications the sol-gel material is used to provide a microporous support matrix in which analyte-sensitive species are entrapped and into which smaller analyte molecules may diffuse. Sensors based on entrapped organic and inorganic dyes, enzymes and other biomolecules have been reported. A range of sensor configurations has been employed, including monoliths, thin films, as well as more elaborate structures. In this paper a selection is presented of recent significant developments in optical chemical sensors which employ sol-gel-derived materials. These developments include the tailoring of sol-gel materials to optimise sensor response, advanced waveguide structures and novel probe-tip sensors. Those issues which remain critical to the eventual deployment of sol-gel sensors are examined. In particular, the problems of leaching, microstructural stability, diffusion-limited response time, and susceptibility to interferents are discussed and some solutions proposed.