Integrated multi-omics analysis for lung adenocarcinoma in Xuanwei, China.
Integrated multi-omics analysis for lung adenocarcinoma in Xuanwei, China.
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宣威地区肺腺癌的多基因组学研究
DOI：
10.18632/aging.205300
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发表时间：
2023-12-13
期刊：
影响因子：
--
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中科院分区：
文献类型：
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背景：宣威肺癌（XWLC）以其高发病率和死亡率而闻名。然而，其分子机制尚不清楚。方法：我们对3例XWLC合并肺腺癌（LUAD）患者的肿瘤和匹配的正常邻近组织进行了全面的转录组学、蛋白质组学和磷酸化蛋白质组学表征。结果：综合转录组和蛋白质组分析揭示了肿瘤中失调的分子和通路，并确定了代谢-疾病耦合增强。非编码RNA广泛参与转录后调控机制，协调LUAD的进展，并部分解释了RNA和蛋白质表达模式之间的分子差异。Phosphoproteome为新的磷酸位点提供了证据支持，报告了核心激酶家族成员和关键激酶途径在代谢、免疫和体内平衡中的潜在作用。此外，通过对比以往的LUAD研究，我们强调宣威LUAD中氧化磷酸化程度较高，并指出VIPR1缺乏加重了代谢功能障碍。结论：我们的综合多组学分析为系统了解XWLC的分子结构提供了强大的资源，并提出了基于氧化还原代谢的治疗机会。
Background: Xuanwei lung cancer (XWLC) is well-known for its high incidence and mortality. However, the molecular mechanism is still unclear. Methods: We performed a comprehensive transcriptomic, proteomic, and phosphoproteomic characterization of tumors and matched normal adjacent tissues from three XWLC patients with lung adenocarcinoma (LUAD). Results: Integrated transcriptome and proteome analysis revealed dysregulated molecules and pathways in tumors and identified enhanced metabolic-disease coupling. Non-coding RNAs were widely involved in post-transcriptional regulatory mechanisms to coordinate the progress of LUAD and partially explained the molecular differences between RNA and protein expression patterns. Phosphoproteome provided evidence support for new phosphate sites, reporting the potential roles of core kinase family members and key kinase pathways involved in metabolism, immunity, and homeostasis. In addition, by comparing with the previous LUAD researches, we emphasized the higher degree of oxidative phosphorylation in Xuanwei LUAD and pointed that VIPR1 deficiency aggravated metabolic dysfunction. Conclusion: Our integrated multi-omics analysis provided a powerful resource for a systematic understanding of the molecular structure of XWLC and proposed therapeutic opportunities based on redox metabolism.
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DOI：
10.1093/bioinformatics/bts251
发表时间：
2012-07-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Jiao X;Sherman BT;Huang da W;Stephens R;Baseler MW;Lane HC;Lempicki RA
通讯作者：
Lempicki RA
影响因子：
64.5
作者：
Gillette, Michael A.;Satpathy, Shankha;Carr, Steven A.
通讯作者：
Carr, Steven A.
影响因子：
5.8
作者：
Cheng, Alice;Grant, Charles E.;Bailey, Timothy L.
通讯作者：
Bailey, Timothy L.
影响因子：
3.9
作者：
Jiang, Wensheng;Xu, Zhiying;Yang, Jun
通讯作者：
Yang, Jun
CaSR 诱导破骨细胞分化并促进肺腺癌骨转移
影响因子：
4.7
作者：
Liu, Lian;Fan, Yichang;Yu, Jing
通讯作者：
Yu, Jing