LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer.
LZTS1 downregulation confers paclitaxel resistance and is associated with worse prognosis in breast cancer.
复制标题
DOI：
10.18632/oncotarget.1630
复制
发表时间：
2014-02-28
期刊：
影响因子：
--
通讯作者：
Vecchione A
中科院分区：
文献类型：
--
作者：
Lovat F;Ishii H;Schiappacassi M;Fassan M;Barbareschi M;Galligioni E;Gasparini P;Baldassarre G;Croce CM;Vecchione A
亮氨酸拉链肿瘤抑制因子1（Leucine Zipper Tumor Suppressor 1，LZTS 1）是一个位于染色体8p22的肿瘤抑制基因，在人类癌症中经常发生改变。在正常组织中，其普遍表达通过稳定微管网络来调节细胞有丝分裂。LZTS1缺陷小鼠胚胎成纤维细胞已被证明具有加速的有丝分裂进程，以及对紫杉烷类微管稳定药物的较高抗性。我们研究Lzts1在乳腺癌细胞紫杉醇耐药中的作用。Lzts1表达下调显著降低体外对紫杉醇的敏感性。我们进一步分析了Lzts1的表达在270原发性乳腺癌标本和16例正常乳腺标本的免疫组化。Lzts1在乳腺癌样本中显著下调，其失调与较高的肿瘤复发率和较差的总生存率相关。此外，Lzts1阴性肿瘤与紫杉类药物治疗后的不良结局相关。因此，我们的数据表明，Lzts1失调参与乳腺癌，其免疫组化评价可能作为乳腺癌治疗的预后因素
The Leucine Zipper Tumor Suppressor 1 (LZTS1) is a tumor suppressor gene, located at chromosome 8p22, which is frequently altered in human cancer. In normal tissue, its ubiquitous expression regulates cell mitosis by the stabilization of microtubule networks. LZTS1-deficient mouse embryonic fibroblasts have been shown to have an accelerated mitotic progression, and a higher resistance to taxanes, microtubule-stabilizing drugs. We investigate the role of Lzts1 in paclitaxel-resistance in breast cancer cells. Downregulation of Lzts1 expression significantly decreases sensitivity to paclitaxel in vitro. We further analyzed Lzts1 expression by immunohistochemistry in 270 primary breast cancer samples and 16 normal breast specimens. Lzts1 was significantly downregulated in breast cancer samples and its deregulation was associated with a higher incidence of tumor recurrence, and to a worse overall survival. Moreover, Lzts1-negative tumors were associated with unfavorable outcome after taxanes-based therapy. Thus our data suggest that Lzts1 deregulation is involved in breast cancer and its immunohistochemical evaluation may serve as a prognostic factor for breast cancer therapy
登录
查看更多内容
影响因子：
3.8
作者：
Esserman, Laura J.;Berry, Donald A.;Cheang, Maggie C. U.;Yau, Christina;Perou, Charles M.;Carey, Lisa;DeMichele, Angela;Gray, Joe W.;Conway-Dorsey, Kathleen;Lenburg, Marc E.;Buxton, Meredith B.;Davis, Sarah E.;van't Veer, Laura J.;Hudis, Clifford;Chin, Koei;Wolf, Denise;Krontiras, Helen;Montgomery, Leslie;Tripathy, Debu;Lehman, Constance;Liu, Minetta C.;Olopade, Olufunmilayo I.;Rugo, Hope S.;Carpenter, John T.;Livasy, Chad;Dressler, Lynn;Chhieng, David;Singh, Baljit;Mies, Carolyn;Rabban, Joseph;Chen, Yunni-Yi;Giri, Dilip;Au, Alfred;Hylton, Nola
通讯作者：
Hylton, Nola
DOI：
10.1001/jama.2011.593
发表时间：
2011-05-11
期刊：
JAMA
影响因子：
--
作者：
Hatzis C;Pusztai L;Valero V;Booser DJ;Esserman L;Lluch A;Vidaurre T;Holmes F;Souchon E;Wang H;Martin M;Cotrina J;Gomez H;Hubbard R;Chacón JI;Ferrer-Lozano J;Dyer R;Buxton M;Gong Y;Wu Y;Ibrahim N;Andreopoulou E;Ueno NT;Hunt K;Yang W;Nazario A;DeMichele A;O'Shaughnessy J;Hortobagyi GN;Symmans WF
通讯作者：
Symmans WF
影响因子：
4.7
作者：
Baffa, Raffaele;Fassan, Matteo;Croce, Carlo M.
通讯作者：
Croce, Carlo M.
影响因子：
8
作者：
Cabeza-Arvelaiz, Y;Sepulveda, JL;Chinault, AC
通讯作者：
Chinault, AC
影响因子：
45.3
作者：
De Laurentiis, Michele;Cancello, Giuseppe;De Placido, Sabino
通讯作者：
De Placido, Sabino