High-mobility group box 1 protein plasma concentrations during septic shock
High-mobility group box 1 protein plasma concentrations during septic shock
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DOI：
10.1007/s00134-007-0691-2
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发表时间：
2007-08-01
影响因子：
38.9
通讯作者：
Bollaert, Pierre-Edouard
中科院分区：
文献类型：
--
作者：
Gibot, Sebastien;Massin, Frederic;Bollaert, Pierre-Edouard
目的：研究感染性休克患者血浆高迁移率族蛋白B1（HMGB 1）浓度及其与器官功能障碍和预后的关系。成人重症监护病房在法国的一所大学医院。患者：42例重症患者感染性休克。方法：动脉血被抽出12小时内入院的血浆HMGB 1浓度的测定，通过ELISA。结果：入院时HMGB 1浓度中位数为4.4ng/ml（IQR 1.2-12.5），存活组与死亡组间无差异。HMGB 1和SOFA评分与乳酸和降钙素原浓度呈正相关。有一个渐进的，但统计学上不显着的HMGB 1浓度下降的幸存者之间，而非幸存者表现出增加HMGB 1水平之间的第1和第3天。第1天和第3天之间，SOFA评分和乳酸盐及降钙素原浓度无显著变化。当在第3天测量时，HMGB 1以66%的灵敏度和67%的特异性区分幸存者和非幸存者，并且浓度大于4 ng/ml与死亡的比值比为5.5（95%CI 1.3-23.6）相关。
Objective: To investigate plasma high- mobility group box 1 protein (HMGB1) concentration and its relationship with organ dysfunction and outcome in septic shock patients.Design and setting: Prospective, noninterventional study. Medical adult intensive care unit at a university hospital in France.Patients: 42 critically ill patients with septic shock.Methods: Arterial blood was drawn within 12 h of admission for the measurement of plasma HMGB1 concentration by ELISA. Repeated sampling was performed on days 3, 7, and 14.Results: Median HMGB1 concentration was 4.4 ng/ml (IQR 1.2-12.5) at admission, with no difference between survivors and nonsurvivors. A positive correlation was observed between HMGB1 and SOFA score and lactate, and procalcitonin concentrations. There was a progressive but statistically nonsignificant decline in HMGB1 concentration among the survivors, while nonsurvivors showed an increase in HMGB1 level between days 1 and 3. SOFA score and lactate and procalcitonin concentrations did not vary significantly between days 1 and 3. When measured on day 3, HMGB1 discriminated survivors from nonsurvivors with 66% sensitivity and 67% specificity, and concentration greater than 4 ng/ml was associated with an odds ratio of death of 5.5 (95% CI 1.3-23.6).