The effects of IL-2 and Treg cells on dendritic cell homeostasis are mediated indirectly via activation of conventional T cells
The effects of IL-2 and Treg cells on dendritic cell homeostasis are mediated indirectly via activation of conventional T cells
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DOI：
10.1002/eji.201445229
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发表时间：
2015-04-01
影响因子：
5.4
通讯作者：
Fazekas de St Groth, Barbara
中科院分区：
文献类型：
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作者：
Bolton, Holly A.;Roediger, Ben;Fazekas de St Groth, Barbara
DC稳态受多种因素影响，包括GM-CSF和Flt 3L的可用性，这两者对DC分化和存活产生积极影响。IL-2和Treg细胞最近被提出作为DC数量的负调节因子。目前尚不清楚它们在免疫缺陷小鼠中的作用是直接的，还是通过响应于IL-2和/或Treg细胞的缺乏而激活常规T细胞介导的。使用一些体内模型，我们已经评估了IL-2和Treg细胞数量对常规脾和LN DC的作用。我们没有发现IL-2或Treg细胞在负调节DC数量中的直接作用的证据。我们的数据表明，在不存在IL-2或Treg细胞的情况下DC的扩增是继发于常规T细胞的活化和增殖的间接效应。
DC homeostasis is influenced by multiple factors, including the availability of GM-CSF and Flt3L, both of which exert positive effects on DC differentiation and survival. IL-2 and Treg cells have recently been proposed as negative regulators of DC numbers. It remains unclear whether their effects in immunosufficient mice are direct, or are mediated via activation of conventional T cells in response to deficiencies of IL-2 and/or Treg cells. Using a number of in vivo models, we have assessed the role of IL-2 and Treg-cell number on conventional splenic and LN DCs. We have found no evidence for a direct role of IL-2 or Treg cells in negatively regulating DC number. Our data indicate that the expansion of DCs in the absence of either IL-2 or Treg cells is an indirect effect secondary to the activation and proliferation of conventional T cells.