Allergy-associated FcRβ is a molecular amplifier of IgE- and lgG-mediated in vivo responses
Allergy-associated FcRβ is a molecular amplifier of IgE- and lgG-mediated in vivo responses
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DOI：
10.1016/s1074-7613(00)80556-7
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发表时间：
1998-04-01
期刊：
影响因子：
32.4
通讯作者：
Kinet, JP
中科院分区：
文献类型：
--
作者：
Dombrowicz, D;Lin, SQ;Kinet, JP
遗传学研究表明Fc受体β链（FcR β）在变态反应发病机制中的作用。FcR β是高亲和力IgE（Fc γ RI）和低亲和力IgG（Fc γ RIII）受体共同的亚基，两者都有助于引发过敏反应。目前的体外数据表明，FcR β可以作为一个积极的或消极的调节器，留下一个机制解释其与特应性的发展不清楚。为了解决这一争议，我们已经产生了新的小鼠模型相关的人Fc受体功能。对这些小鼠中Fc γ RI和Fc γ RIII依赖性反应的分析提供了明确的遗传证据，即FcR β作为早期和晚期肥大细胞反应的放大器，并且显著地作为体内过敏反应的放大器。
A role for the Fc receptor beta chain (FcR beta) in the pathogenesis of allergy has been suggested by genetic studies. FcR beta is a subunit common to the high-affinity IgE (Fc epsilon RI) and low-affinity IgG (Fc gamma RIII) receptors, both of which contribute to the initiation of allergic reactions. Current in vitro data suggest that FcR beta can function as either a positive or negative regulator, leaving a mechanistic explanation for its association with the development of atopy unclear. To address this controversy, we have generated novel mouse models relevant to human Fc receptor function. Analysis of Fc epsilon RI- and Fc gamma RIII-dependent responses in these mice provides unequivocal genetic evidence that FcR beta functions as an amplifier of early and late mast cell responses and, remarkably, in vivo anaphylactic responses.