Photosensitive dermatitis induced by flutamide
Photosensitive dermatitis induced by flutamide
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氟他胺诱发光敏性皮炎
DOI：
10.1111/j.1365-2133.1996.tb01532.x
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发表时间：
1996
影响因子：
10.3
通讯作者：
M. Furue
中科院分区：
文献类型：
--
作者：
M. Fujimoto;Kazuya Kikuchi;S. Imakado;M. Furue
两代患者(或，包括推定诊断的患者，四代患者中有五名)患有以单纯肢端受累为特征的出血性病变的Darier病。我们不能排除第三个患者的皮损可能是典型的Darier病的最早表现，但这在患者1和2中似乎不太可能，他们在十几岁早期就开始出现手部皮损，现在42岁和38岁。虽然出血性斑疹极为罕见，但它是达里尔氏病的特征。然而，最近在遗传性大疱性表皮松解症的一种变种-大疱性棘层松解症中描述了类似的皮损。在我们的家系中，存在一个典型的Darier病病例，同时在我们的患者中发现其他特征的肢端表现，特别是指甲营养不良和掌凹，排除了棘松性大疱性表皮松解症的诊断。
patients in two generations (or, including cases with a presumptive diagnosis, five patients in four generations), had Darier's disease characterized by exclusive acral involvement with haemorrhagic lesions. We cannot exclude that the third patient's lesions may represent the earliest manifestations of a classical Darier's disease, hut this seems unlikely in patients 1 and 2, who first developed hand lesions in their early teens and are now aged 42 and 38. Although extremely rare, haemorrhagic macules are distinctive for Darier's disease. However, similar lesions have heen recently described in a variant of Inherited epidermolysis bullosa, acantholytic epidermolysis bullosa.^ The presence, in our pedigree, of a case of classical Darier's disease, and the concomitant finding in our patients of other characteristic acral manifestations, in particular nail dystrophy and palmar pits, excludes a diagnosis of acantholytic epidermolysis bullosa.