Validating Measures of Real-World Outcome: The Results of the VALERO Expert Survey and RAND Panel
Validating Measures of Real-World Outcome: The Results of the VALERO Expert Survey and RAND Panel
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DOI：
10.1093/schbul/sbp044
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发表时间：
2011-03-01
影响因子：
6.6
通讯作者：
Harvey, Philip D.
中科院分区：
文献类型：
--
作者：
Leifker, Feea R.;Patterson, Thomas L.;Harvey, Philip D.
背景：精神分裂症患者自我报告的功能和线人报告之间存在相当大的差异。不清楚这些差异是来自所使用的工具，还是来自不同举报人的观点。日常真实世界结果验证（VALERO）研究的目标是通过使用类似于测量和治疗研究以改善精神分裂症认知（MATRICS）倡议的多步骤过程选择最佳量表和线人，来加强对社会，住宅和职业领域真实世界（RW）结果的测量。方法：48位专家就衡量RW结局的最佳尺度提出了他们的意见。提名了59项措施。研究人员选择了11个被提名最多的量表，这些量表拥有最多的有效性数据，并且最能代表感兴趣的领域。向担任兰德公司专题小组成员的其他专家提供了资料。小组成员对每个措施在多个先验领域的适用性进行了评级。对不一致的评级进行讨论，直至达成共识。结果如下：在兰德小组之后，选择在每个量表类别（混合、社会功能和日常生活技能）的各种标准中得分最高的2个量表用于VALERO的第一个子研究。选择的量表包括生活质量量表、特定功能水平量表、社会行为量表、社会功能量表、独立生活技能量表和生活技能概况。讨论内容：结果表明，虽然有显着的局限性，目前的量表用于评估RW的结果在精神分裂症，共识是可能的。此外，一些现有的工具被评为有用的衡量社会，住宅和职业成果。
Background: People with schizophrenia demonstrate considerable discrepancy between self-reported functioning and informant reports. It is not clear whether these discrepancies originate from the instruments used or from the perspectives of different informants. The goal of the Validation of Everyday Real-World Outcomes (VALERO) Study is to enhance the measurement of real-world (RW) outcomes in the social, residential, and vocational domains through selection of optimal scales and informants using a multistep process similar to the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. Methods: Forty-eight experts provided their opinion regarding the best scales measuring RW outcomes. Fifty-nine measures were nominated. The investigators selected the 11 scales that were the most highly nominated, had the most published validity data, and best represented the domains of interest. Information was provided to other experts who served as RAND panelists. Panelists rated each measure for its suitability across multiple a priori domains. Discrepant ratings were discussed until consensus was reached. Results: Following the RAND Panel, the 2 scales that scored highest across the various criteria for each of the classes of scales (hybrid, social functioning, and everyday living skills) were selected for use in the first substudy of VALERO. The scales selected were the Quality-of-Life Scale, Specific Levels of Functioning Scale, Social Behavior Schedule, Social Functioning Scale, Independent Living Skills Schedule, and Life Skills Profile. Discussion: The results show that although there are significant limitations with current scales used for the assessment of RW outcome in schizophrenia, a consensus is possible. Further, several existing instruments were rated as useful for measuring social, residential, and vocational outcomes.