Fungal Biofilms, Drug Resistance, and Recurrent Infection
Fungal Biofilms, Drug Resistance, and Recurrent Infection
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DOI：
10.1101/cshperspect.a019729
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发表时间：
2014-10-01
影响因子：
5.4
通讯作者：
Andes, David R.
中科院分区：
文献类型：
--
作者：
Desai, Jigar V.;Mitchell, Aaron P.;Andes, David R.
生物膜是一种表面相关的微生物群落。不同的真菌能够生长生物膜。这种生长形式对感染生物学的意义在于，植入设备上生物膜的形成是反复感染的主要原因。生物膜对药物的敏感性也很有限，使设备相关感染极难治疗。在许多种感染过程中，甚至在没有植入设备的情况下，也会发生生物膜样生长。本文综述了目前对真菌生物被膜形成、遗传控制以及生物被膜耐药的基础的认识。
A biofilm is a surface-associated microbial community. Diverse fungi are capable of biofilm growth. The significance of this growth form for infection biology is that biofilm formation on implanted devices is a major cause of recurrent infection. Biofilms also have limited drug susceptibility, making device-associated infection extremely difficult to treat. Biofilm-like growth can occur during many kinds of infection, even when an implanted device is not present. Here we summarize the current understanding of fungal biofilm formation, its genetic control, and the basis for biofilm drug resistance.