Oxidative stress and metabolic syndrome in a Japanese female population
Oxidative stress and metabolic syndrome in a Japanese female population
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DOI：
10.1111/j.1741-6612.2011.00571.x
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发表时间：
2012-06-01
影响因子：
1.6
通讯作者：
Yamada, Toshiyuki
中科院分区：
文献类型：
--
作者：
Kotani, Kazuhiko;Yamada, Toshiyuki
目的：临床医学环境中评价氧化应激的方法之一是活性氧代谢产物（d-ROMs）试验。虽然代谢综合征（MetS）被认为是一种氧化状态，但MetS中的氧化状态尚未使用该测试进行充分检查。本研究的目的是在日本女性人群中调查氧化应激（通过d- rom测试评估）与MetS成分数之间的可能关联。方法：横断面测定无心血管疾病、不吸烟、不服用药物的女性（n= 180，平均年龄60±10（标准差）岁）的血清氧化能力（通过d-ROMs试验测定）。他们的met状态由国家胆固醇教育计划成人治疗小组的建议确定，对日本人群进行了轻微修改。结果：met患者（n= 60, 362 +/- 53 CARR U）的d- rom氧化能力显著高于未met患者（n= 120, 324 +/- 55 CARR U, P < 0.01）。此外，d- rom氧化能力的显著增加与MetS组分数的增加密切相关（趋势P < 0.01）。结论：这些结果表明，在该人群中，氧化能力（通过d- rom）和MetS成分数量之间存在显著的正相关。需要进一步的研究来建立该测试在MetS实践中的临床应用，并阐明所观察到的关系的生物学机制。
Aim: One of the methods to evaluate oxidative stress in clinical medical settings is the reactive oxygen metabolites (d-ROMs) test. While metabolic syndrome (MetS) is considered an oxidative condition, the oxidative status in MetS has not been fully examined using this test. The aim of the present study was to investigate the possible association between oxidative stress as evaluated by the d-ROMs test and the MetS component number, in a Japanese female population. Methods: The serum oxidant capacity (measured by the d-ROMs test) was cross-sectionally determined in cardiovascular disease-free and non-smoking women who were not taking medications (n= 180; mean age, 60 +/- 10 (standard deviation) years). Their MetS state was determined by the National Cholesterol Education Program Adult Treatment Panel recommendations with minor modifications for a Japanese population. Results: Patients with MetS (n= 60, 362 +/- 53 CARR U) showed a significantly higher oxidant capacity by d-ROMs than those without MetS (n= 120, 324 +/- 55 CARR U, P < 0.01). Moreover, the significant increase in the oxidant capacity by d-ROMs was closely associated with an increase in the MetS component number (trend P < 0.01). Conclusions: These results showed a significantly positive association between the oxidant capacity (by d-ROMs) and the MetS component number in this population. Further studies are required to establish the clinical applications of this test to MetS practice and clarify the biological mechanisms of the observed relationships.