Respiratory disease due to parainfluenza virus in adult leukemia patients
Respiratory disease due to parainfluenza virus in adult leukemia patients
复制标题
DOI：
10.1007/s10096-002-0864-4
复制
发表时间：
2003-02-01
影响因子：
4.5
通讯作者：
Bodey, GP
中科院分区：
文献类型：
--
作者：
Marcolini, JA;Malik, S;Bodey, GP
白血病患者中人类副流感病毒（HPIV）的报告仅限于少数病例或作为一般调查的一部分。为了扩大对这一患者群体中这些感染的了解，我们对 1994 年 7 月至 1997 年 12 月期间在德克萨斯大学 M.D. 安德森癌症中心治疗的 1,787 名白血病患者中确定了 HPIV 感染的频率和临床病程。在进行呼吸道病毒培养的 770 名患者中，从 47 名患者（6.2%）中分离出了 HPIV。 47 例 HPIV 感染中，39 例为 HPIV 3 型。 26 名患者出现肺炎，相关死亡率为 27%。多变量分析显示，淋巴细胞绝对计数低和肺炎与死亡率增加相关。并发呼吸道和其他感染与肺炎发生率增加有关。只有五名肺炎患者接受了抗病毒治疗，其中四人在感染后幸存下来。白血病患者的 HPIV 感染通常与肺炎相关，并且淋巴细胞减少症患者的肺炎死亡率很高。
Reports of human parainfluenza viruses (HPIV) in patients with leukemia have been limited to a few cases or as a portion of general surveys. In order to expand the knowledge of these infections in this patient group, the frequency and clinical course of HPIV infections was determined among 1,787 patients with leukemia treated at The University of Texas M.D. Anderson Cancer Center between July 1994 and December 1997. HPIV was isolated from 47 (6.2%) of the 770 patients who were cultured for respiratory viruses. HPIV type 3 accounted for 39 of the 47 HPIV infections. Twenty-six patients developed pneumonia, and the associated mortality was 27%. Multivariate analysis revealed that a low absolute lymphocyte count and pneumonia were associated with increased mortality. Concurrent respiratory and other infections were associated with an increased frequency of pneumonia. Only five patients with pneumonia received antiviral therapy and four of them survived the infection. HPIV infection in leukemic patients is frequently associated with pneumonia and the mortality rate from pneumonia is substantial among lymphopenic patients.