Mechanisms of self-nonself discrimination and possible clinical relevance.
Mechanisms of self-nonself discrimination and possible clinical relevance.
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DOI：
10.2217/imt.09.29
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发表时间：
2009-07
期刊：
影响因子：
2.8
通讯作者：
von Boehmer H
中科院分区：
文献类型：
--
作者：
Daniel C;Nolting J;von Boehmer H
这篇综述讨论了导致免疫耐受的不同机制，例如未成熟T细胞的胸腺内删除、调节性T细胞的胸腺内和胸腺外产生、调节性T细胞的效应机制以及体内和体外调节性T细胞胸腺外产生所涉及的分子途径。这些分子机制应能使研究人员制定旨在特异性预防有害免疫反应的临床方案，从而取代常常具有致命后果的不加选择的免疫抑制。
This review discusses different mechanisms that result in immunological tolerance, such as intrathymic deletion of immature T cells, intrathymic and extrathymic generation of regulatory T cells, effector mechanisms of regulatory T cells as well as molecular pathways involved in extrathymic generation of regulatory T cells in vivo and in vitro. These molecular mechanisms should enable investigators to develop clinical protocols aiming at the specific prevention of unwanted immune responses, thereby replacing indiscriminate immunosuppression that often has fatal consequences.