Hyper-adhesion: a new concept in cell-cell adhesion
Hyper-adhesion: a new concept in cell-cell adhesion
复制标题
DOI：
10.1042/bst0360195
复制
发表时间：
2008-04-01
影响因子：
3.9
通讯作者：
Kimura, Tomomi E.
中科院分区：
文献类型：
--
作者：
Garrod, David;Kimura, Tomomi E.
我们已经发展了一种新的细胞-细胞粘附概念，称为“超粘附”，即桥粒所采用的非常强的粘附。这种独特的桥粒性质解释了它们在桥粒-中间丝复合物中提供细胞间连接的能力。这些联系是疾病的目标，导致复杂的破坏，造成严重后果。超粘附是组织中桥粒的特征，并且被认为是由桥粒钙粘蛋白的胞外结构域的高度有序排列引起的，所述胞外结构域锁定它们的结合相互作用，使得其高度抵抗破坏。这种有序排列可以通过桥粒斑块的类似有序的分子结构来反映并依赖于桥粒斑块的类似有序的分子结构。超粘附可通过涉及蛋白激酶C的细胞信号传导下调至更弱的粘附状态，蛋白激酶C易位至桥粒斑块。下调发生在伤口边缘上皮细胞，似乎伴随着有序排列的丧失，导致桥粒采用粘附连接的较弱粘附特征类型。我们回顾了超粘附的证据，并推测其机制的分子基础。
we have developed a new concept of cell-cell adhesion termed 'hyper-adhesion', the very strong adhesion adopted by desmosomes. This uniquely desmosomal property accounts for their ability to provide the intercellular links in the desmosome-intermediate filament complex. These links are targeted by diseases, resulting in disruption of the complex with severe consequences. Hyper-adhesion is characteristic of desmosomes in tissues and is believed to result from a highly ordered arrangement of the extracellular domains of the desmosomal cadherins that locks their binding interaction so that it is highly resistant to disruption. This ordered arrangement may be reflected by and dependent upon a similarly ordered molecular structure of the desmosomal plaque. Hyper-adhesion can be down-regulated to a more weakly adhesive state by cell signalling involving protein kinase C, which translocates to the desmosomal plaque. Down-regulation takes place in wound edge epithelium and appears to be accompanied by loss of the ordered arrangement causing desmosomes to adopt the type of weaker adhesion characteristic of adherens junctions. We review the evidence for hyper-adhesion and speculate on the molecular basis of its mechanism.