Multi-parameter cardiac magnetic resonance imaging detects anthracycline-induced cardiotoxicity in rabbits model.
Multi-parameter cardiac magnetic resonance imaging detects anthracycline-induced cardiotoxicity in rabbits model.
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DOI：
10.1016/j.heliyon.2023.e21845
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发表时间：
2023-11
期刊：
影响因子：
4
通讯作者：
Jian, Wang
中科院分区：
文献类型：
--
作者：
Hu, Yurou;Ma, Peisong;Chen, Lin;Liu, Juan;Shang, Yongning;Jian, Wang
心脏磁共振（CMR）定量T1和T2标测提供了一种非侵入性手段来评估早期心脏毒性变化。本研究旨在确定蒽环类药物诱导的心脏毒性（AIC）中心肌损伤的最早CMR指标，并阐明这些CMR指标与相关病理指标之间的联系。共34只家兔以1 mg/kg/周的剂量给予阿霉素。该研究纳入了六个3 T CMR扫描时间点：基线以及间隔四周、六周、八周、十二周和十六周。电影、T1和T2标测序列评估了左心室射血分数（LVEF）、天然T1、细胞外容积分数（ECV）和T2值。在每个时间点后，处死三只兔用于组织学分析，包括苏木精和伊红（H&E）、Masson、TUNEL和微血管密度（MVD）染色。统计分析采用斯皮尔曼相关分析和线性混合模型分析。随着时间的推移，记录了LVEF、自体T1、T2和ECV的不同程度的变化。LVEF从基线53.4 ± 3.2%下降至12周时的49.0 ± 2.6%，p < 0.001。天然T1值从基线（1396.5 ± 79.2 ms）增加至8周（1498.8 ± 95.4 ms，p < 0.001）。T2值在开始治疗的4周内从基线（36.6 ± 3.3 ms）增加（37.5 ± 3.4，p = 0.02），并在16周内保持升高（42.8 ± 0.3，p < 0.01）。与基线（30.2 ± 2.5%）相比，8周时ECV升高（33.9 ± 3.8%，p = 0.005）。到第12周，心肌水肿和CVF增加明显（分别为p = 0.04和p = 0.001）。CMR阳性的ROC曲线下面积和金标准分别为0.87（T2-ROC，4周）和0.92（LVEF和BNP-ROC，12周）。T1和T2标测是检测和监测心脏毒性的有效工具。T2值延长是最一致和最早发生的指标。蒽环类药物可能对心肌组织特性产生影响。T2值和ECV值可预测蒽环类药物引起的亚临床心肌损伤。最早和最稳定的CMR指标是T2值的延长。
Cardiac magnetic resonance (CMR) quantitative T1 and T2 mapping offers a non-invasive means to evaluate early cardiotoxicity changes. This study aimed to pinpoint the earliest CMR indicators of myocardial injury in Anthracycline-induced cardiotoxicity (AIC) and to elucidate the connections between these CMR indicators and associated pathological indicators. A total of 34 rabbits were administered doxorubicin at a dosage of 1 mg/kg/weekly. The study incorporated six 3T CMR scan time points: baseline, and at intervals of four, six, eight, twelve, and sixteen weeks. Cine, T1 and T2 mapping sequences assessed the left ventricular ejection fraction (LVEF), native T1, extracellular volume fraction (ECV), and T2 values. Following each time point, three rabbits were sacrificed for histological analysis involving Hematoxylin and eosin (H&E), Masson, TUNEL, and microvascular density (MVD) stains. Spearman correlations and linear mixed model analysis served in the statistical analysis. Diverse degrees of alternation were recorded in LVEF, native T1, T2, and ECV over time. LVEF declined to 49.0 ± 2.6 % at 12 weeks from the baseline of 53.4 ± 3.2 %, p < 0.001. Native T1 values increase from the baseline (1396.5 ± 79.2 ms) until 8 weeks (1498.8 ± 95.4 ms, p < 0.001). T2 values increased from the baseline (36.6 ± 3.3 ms) within 4 weeks of initiation (37.5 ± 3.4, p = 0.02) and remained elevated through 16 weeks (42.8 ± 0.3, p < 0.01). ECV was elevated at 8 weeks (33.9 ± 3.8 %, p = 0.005) compared to the baseline (30.2 ± 2.5 %). By week 12, myocardial edema and increased CVF were apparent (p = 0.04 and = 0.001, respectively). The area under ROC curve for positive CMR presence and the gold standards were 0.87 (T2-ROC, 4 weeks) and 0.92 (LVEF&BNP-ROC, 12 weeks). T1 and T2 mapping are effective tools for cardiotoxicity detection and monitoring. The prolongation of T2 value emerged as the most consistent and early-onset indicator. Anthracycline may cause an effect on myocardial tissue characterization. T2 values and ECV values can predict subclinical myocardial injury with anthracyclines. The earliest and most stable CMR indicator was the prolongation of the T2 value.
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影响因子：
--
作者：
Robinson EL;Azodi M;Heymans S;Heggermont W
通讯作者：
Heggermont W
影响因子：
10.8
作者：
Galán-Arriola C;Vílchez-Tschischke JP;Lobo M;López GJ;de Molina-Iracheta A;Pérez-Martínez C;Villena-Gutiérrez R;Macías Á;Díaz-Rengifo IA;Oliver E;Fuster V;Sánchez-González J;Ibanez B
通讯作者：
Ibanez B
影响因子：
3.2
作者：
Sonawane, Varsha K.;Mahajan, Umesh B.;Patil, Chandragouda R.
通讯作者：
Patil, Chandragouda R.
DOI：
10.1016/j.jaccao.2021.04.011
发表时间：
2021-06
期刊：
JACC. CardioOncology
影响因子：
--
作者：
O'Quinn R;Ferrari VA;Daly R;Hundley G;Baldassarre LA;Han Y;Barac A;Arnold A
通讯作者：
Arnold A
影响因子：
3.4
作者：
Park CJ;Branch ME;Vasu S;Meléndez GC
通讯作者：
Meléndez GC