Efficiency of intermittent exercise on adiposity and fatty liver in rats fed with high-fat diet
Efficiency of intermittent exercise on adiposity and fatty liver in rats fed with high-fat diet
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DOI：
10.1038/oby.2008.339
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发表时间：
2008-10-01
期刊：
影响因子：
6.9
通讯作者：
Damaso, Ana R.
中科院分区：
文献类型：
--
作者：
Sene-Fiorese, Marcela;Duarte, Fernanda O.;Damaso, Ana R.
目的：本研究旨在研究和比较连续或间歇运动对高脂饮食大鼠肥胖和脂肪肝的影响。方法和程序：Wistar大鼠根据饮食组成-普通饮食（C）或高脂饮食（H）-和运动类型-久坐（S），连续（CE），或间歇（IE）运动。CE组游泳90分钟/天，IE组游泳3 × 30分钟/天（在4小时的时间间隔）;两组在8周内每周锻炼5天。每天记录体重和摄食量。采用重量分析法，通过将（H2O）-H-3掺入腹膜后（RET）、附睾（EPI）和内脏（维斯）白色脂肪组织、棕色脂肪组织（BAT）、肝脏（L）和腓肠肌（GAST）中的皂化脂质，测定体内脂肪生成速率。总胆固醇，高密度脂蛋白（HDL）-胆固醇，和三酰甘油（TG）进行了analysed.Results：本研究的主要发现是，IE比CE更有效地减少高脂饮食和久坐的不良反应。有一个改善的血脂和减少食物摄入量，体重增加，内脏和中枢性肥胖，脂肪肝，有助于控制肥胖和其他合并症，包括非酒精性脂肪肝diseases.Discussion：早期的研究已经讨论了饮食消费对肥胖的影响及其与慢性疾病和肥胖的关系。本研究探讨了高脂饮食和不同类型的运动对大鼠体重增加、肥胖、脂肪肝和血脂的影响。结果可能取决于锻炼，每次锻炼的时间，年龄，性别和实验时间。
Objective: This study aimed to examine and compare the effects of continuous or intermittent exercises on adiposity and fatty liver in rats fed with high-fat diet.Methods and Procedures: Wistar rats were divided according to diet composition-chow diet (C) or high-fat diet (H)-and kinds of exercise-sedentary (S), continuous (CE), or intermittent (IE) exercises. The CE group swam 90 min/day, and the IE group swam 3 x 30 min/day (at 4-h intervals between sessions); both groups exercised 5 days/week during 8 weeks. Body weight and food intake were recorded daily. Lipogenesis rate in vivo was determined by the incorporation of (H2O)-H-3 into saponified lipids in retroperitoneal (RET), epididymal (EPI), and visceral (VIS) white adipose tissues, brown adipose tissue (BAT), liver (L), and gastrocnemius muscle (GAST) using the gravimetric method. Total cholesterol, high-density lipoprotein (HDL)-cholesterol, and triacylglycerol (TG) were analyzed.Results: The major finding of this study is that IE was more efficient than CE in reducing the adverse effects of high-fat diet and sedentarism. There was an improvement in the lipid profile and a reduction in food intake, body weight gain, visceral and central adiposity, and fatty liver, contributing to the control of obesity and other comorbidities, including nonalcoholic fat liver diseases.Discussion: Earlier studies have discussed the effects of diet consumption on adiposity and their relation to chronic diseases and obesity. This study discusses the effects of high-fat diet consumption and the different kinds of exercise on weight gain, adiposity, fatty liver, and lipid profile in rats. The results may depend on the exercise, time of each session, age, gender, and experimental period.