Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans.
Skeletal muscle myofilament adaptations to aging, disease, and disuse and their effects on whole muscle performance in older adult humans.
复制标题
DOI：
10.3389/fphys.2014.00369
复制
发表时间：
2014
影响因子：
4
通讯作者：
Toth MJ
中科院分区：
文献类型：
--
作者：
Miller MS;Callahan DM;Toth MJ
骨骼肌收缩功能随着衰老、疾病和废用而下降。体内肌肉的收缩功能取决于多种因素，但力、收缩速度和发电能力最终源自单根肌纤维的贡献总和。反过来，这些纤维的收缩性能取决于它们表达的肌丝蛋白的异构体和功能，其中肌球蛋白表达及其机械和动力学特征起着主导作用。因此，肌丝蛋白生物学的改变可能导致这些情况下功能限制和残疾的发展。最近的研究表明，这些情况与由于肌丝蛋白表达减少和/或肌球蛋白-肌动蛋白跨桥相互作用的变化导致的单纤维性能改变有关。此外，细胞和肌丝水平的适应与整个肌肉和全身性能的下降有关。值得注意的是，与老年男性相比，这些不同的情况对老年女性的肌丝和单纤维功能的影响往往更大，这可能部分导致了她们较高的残疾率。为了保持功能并针对两性的衰老、疾病和废用提供最适当和有效的对策，需要更全面地了解肌丝适应对老年男性和女性功能障碍的影响及其对组织水平功能和活动障碍的影响。
Skeletal muscle contractile function declines with aging, disease, and disuse. In vivo muscle contractile function depends on a variety of factors, but force, contractile velocity and power generating capacity ultimately derive from the summed contribution of single muscle fibers. The contractile performance of these fibers are, in turn, dependent upon the isoform and function of myofilament proteins they express, with myosin protein expression and its mechanical and kinetic characteristics playing a predominant role. Alterations in myofilament protein biology, therefore, may contribute to the development of functional limitations and disability in these conditions. Recent studies suggest that these conditions are associated with altered single fiber performance due to decreased expression of myofilament proteins and/or changes in myosin-actin cross-bridge interactions. Furthermore, cellular and myofilament-level adaptations are related to diminished whole muscle and whole body performance. Notably, the effect of these various conditions on myofilament and single fiber function tends to be larger in older women compared to older men, which may partially contribute to their higher rates of disability. To maintain functionality and provide the most appropriate and effective countermeasures to aging, disease, and disuse in both sexes, a more thorough understanding is needed of the contribution of myofilament adaptations to functional disability in older men and women and their contribution to tissue level function and mobility impairment.
登录
查看更多内容
影响因子：
15.9
作者：
Acharyya, S;Ladner, KJ;Guttridge, DC
通讯作者：
Guttridge, DC
影响因子：
8.8
作者：
Eley, H. L.;Skipworth, R. J. E.;Deans, D. A. C.;Fearon, K. C. H.;Tisdale, M. J.
通讯作者：
Tisdale, M. J.
影响因子：
5.5
作者：
D'Antona, G;Pellegrino, MA;Bottinelli, R
通讯作者：
Bottinelli, R
影响因子：
3.3
作者：
Frontera, Walter R.;Reid, Kieran F.;Fielding, Roger A.
通讯作者：
Fielding, Roger A.
影响因子：
24.3
作者：
Fermoselle, Clara;Rabinovich, Roberto;Barreiro, Esther
通讯作者：
Barreiro, Esther