E3 Ubiquitin Ligases in Endothelial Dysfunction and Vascular Diseases: Roles and Potential Therapies
E3 Ubiquitin Ligases in Endothelial Dysfunction and Vascular Diseases: Roles and Potential Therapies
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DOI：
10.1097/fjc.0000000000001441
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Yisong Qian
中科院分区：
文献类型：
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作者：
Yihan Wang;Yixiong Zhan;Linsiqi Wang;Xuan Huang;Hong-Bo Xin;Mingui Fu;Yisong Qian
ABSTRACT.Ubiquitin E3 ligases are a structurally conserved family of enzymes that exert a variety of regulatory functions in immunity, cell death, and tumorigenesis via the ubiquitination of target proteins. Emerging evidence has shown that E3 ubiquitin ligases play crucial roles in the pathogenesis of endothelial dysfunction and related vascular diseases. Here we reviewed the new findings of E3 ubiquitin ligases in regulating endothelial dysfunction, including endothelial junctions and vascular integrity, endothelial activation, and endothelial apoptosis. The critical role and potential mechanism of E3 ubiquitin ligases in vascular diseases such as atherosclerosis, diabetes, hypertension, pulmonary hypertension, and acute lung injury were summarized. Finally, the clinical significance and potential therapeutic strategies associated with regulation of E3 ubiquitin ligases were also proposed.
