Diabetes and raised blood glucose as risk factors for future suicide: cohort study of 1 234 927 Korean men and women
Diabetes and raised blood glucose as risk factors for future suicide: cohort study of 1 234 927 Korean men and women
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DOI：
10.1136/jech-2011-200464
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发表时间：
2012-07-01
影响因子：
6.3
通讯作者：
Jee, Sun Ha
中科院分区：
文献类型：
--
作者：
Batty, G. David;Kivimaki, Mika;Jee, Sun Ha
背景在选定的研究中，糖尿病的诊断已被证明是自杀的危险因素。血糖和未来的suiction.Aim之间的联系还有待检查，如果糖尿病和血糖水平与自杀riskofsuiction.Methods的韩国癌症预防研究是一个队列的1 329 525人（482 618名妇女）年龄在30-95岁的基线。检测空腹血清标本的血糖，并根据现有定义将糖尿病状态分为五组。研究成员的死亡率超过14 years.Results有472自杀死亡（男性389人，女性83人）在后续。男性糖尿病与自杀死亡呈“J”型关系。因此，虽然2型糖尿病患者的自杀率最高，并且随着血糖水平的降低，自杀风险逐渐下降，但在低正常组中观察到了一种变化。类似的结果是明显的妇女，虽然没有提高风险的最低血糖group.Conclusion在目前的队列中，糖尿病（现有的和研究检测），但不提高血糖是完成自杀的危险因素。
Background A diagnosis of diabetes has been shown to be a risk factor for suicide in selected studies. The link between blood glucose and future suicide has yet to be examined.Aim To examine if diabetes and blood glucose level are associated with a raised risk of suicide.Methods The Korean Cancer Prevention Study is a cohort of 1 329 525 individuals (482 618 women) aged 30-95 years at baseline. A fasting serum specimen was assayed for blood glucose, and diabetes status was categorised into five groups based on existing definitions. Study members were followed for mortality experience over 14 years.Results There were 472 suicide deaths (389 in men and 83 in women) during the follow-up. In men, there was a 'J'-shaped diabetes-suicide death relation. Thus, while the highest suicide rates were apparent in those with type 2 diabetes and there was an incremental fall in suicide risk with decreasing blood glucose level, an inflection was seen in the low-normal group. Similar results were apparent in women, although there was no raised risk in the lowest blood glucose group.Conclusion In the present cohort, diabetes (both existing and study detected) but not raised blood glucose was a risk factor for completed suicide.