A method for assessing quality of control from glucose profiles
A method for assessing quality of control from glucose profiles
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DOI：
10.1111/j.1464-5491.2007.02119.x
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发表时间：
2007-07-01
影响因子：
3.5
通讯作者：
Matthews, D. R.
中科院分区：
文献类型：
--
作者：
Hill, N. R.;Hindmarsh, P. C.;Matthews, D. R.
目的作为实践中的多个评估血糖浓度全天增加糖尿病患者，有必要为低血糖和hyperglycemia.Methods的临床风险的血糖控制加权评估，我们已经开发出一种方法来报告的风险程度，其中血糖档案代表。50位糖尿病专家为40种血糖浓度的范围分配了风险值。他们的反应进行了总结，并推导出一个通用的功能，贫血的风险。将该函数应用于患者血糖曲线，以生成称为血糖风险评估糖尿病方程（GRADE）的综合风险评分。然后分别使用平均值和对低血糖、正常血糖、高血糖范围加权风险评分的相对贡献百分比报告GRADE评分，例如GRADE（低血糖%、正常血糖%、高血糖%）。非糖尿病受试者的动态血糖监测曲线GRADE = 1.1，1型糖尿病动态血糖监测GRADE = 8.09 2型糖尿病患者家庭血糖监测GRADE = 9.97（2%，7%，91%）。结论血糖谱的GRADE评分概括了与血糖谱相关的危险程度。值< 5对应于正常血。GRADE评分可简单地从任何血糖曲线生成，并可用作HbA（1c）的辅助，以报告与血糖变异性相关的风险程度。
Aim As the practice of multiple assessments of glucose concentration throughout the day increases for people with diabetes, there is a need for an assessment of glycaemic control weighted for the clinical risks of both hypoglycaemia and hyperglycaemia.Methods We have developed a methodology to report the degree of risk which a glycaemic profile represents. Fifty diabetes professionals assigned risk values to a range of 40 blood glucose concentrations. Their responses were summarised and a generic function of glycaemic risk was derived. This function was applied to patient glucose profiles to generate an integrated risk score termed the Glycaemic Risk Assessment Diabetes Equation (GRADE). The GRADE score was then reported by use of the mean value and the relative percent contribution to the weighted risk score from the hypoglycaemic, euglycaemic, hyperglycaemic range, respectively, e.g. GRADE (hypoglycaemia%, euglycaemia%, hyperglycaemia%).Results The GRADE scores of indicative glucose profiles were as follows: continuous glucose monitoring profile non-diabetic subjects GRADE = 1.1, Type 1 diabetes continuous glucose monitoring GRADE = 8.09 (20%, 8%, 72%), Type 2 diabetes home blood glucose monitoring GRADE = 9.97 (2%, 7%, 91%).Conclusions The GRADE score of a glucose profile summarises the degree of risk associated with a glucose profile. Values < 5 correspond to euglycaemia. The GRADE score is simple to generate from any blood glucose profile and can be used as an adjunct to HbA(1c) to report the degree of risk associated with glycaemic variability.