Intersections between pulmonary development and disease.
Intersections between pulmonary development and disease.
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DOI：
10.1164/rccm.201103-0495pp
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发表时间：
2011-08
影响因子：
24.7
通讯作者：
J. Whitsett;H. Haitchi;Yutaka Maeda
中科院分区：
文献类型：
--
作者：
J. Whitsett;H. Haitchi;Yutaka Maeda
细胞、分子和发育生物学的最新进展彻底改变了我们关于器官发生过程的概念，这对我们理解肺形成和肺部疾病的发病机制具有重要意义。肺部研究人员长期以来一直在争论发育过程是否在肺的正常修复或慢性肺部疾病中重演。尽管参与肺形态发生的细胞事件和引起肺部疾病的细胞事件可能包括不同的过程，但越来越多的证据表明，许多肺部疾病的发病机制涉及在正常肺发育过程中调节细胞生长、规范和分化的相同遗传机制。
Recent advances in cellular, molecular, and developmental biology have revolutionized our concepts regarding the process of organogenesis that have important implications for our understanding of both lung formation and pulmonary disease pathogenesis. Pulmonary investigators have long debated whether developmental processes are recapitulated during normal repair of the lung or in the setting of chronic pulmonary diseases. Although the cellular events involved in lung morphogenesis and those causing pulmonary disease are likely to include processes that are distinct, there is increasing evidence that the pathogenesis of many lung disorders involves the same genetic machinery that regulates cell growth,specification, and differentiation during normal lung development.