Mapping of a gene for Parkinson's disease to chromosome 4q21-q23
Mapping of a gene for Parkinson's disease to chromosome 4q21-q23
复制标题
DOI：
10.1126/science.274.5290.1197
复制
发表时间：
1996-11-15
期刊：
影响因子：
56.9
通讯作者：
Duvoisin, RC
中科院分区：
文献类型：
--
作者：
Polymeropoulos, MH;Higgins, JJ;Duvoisin, RC
帕金森病（PD）是仅次于阿尔茨海默病的第二种最常见的神经退行性疾病，影响50岁以上人口的约1%。最近的研究已经证实了PD的显着的家族聚集性和大量的大型多病例家庭已被记录。染色体4 q21-q23上的遗传标记被发现与常染色体显性PD的大家族中的PD表型连锁，标记D4 S2380的Z（max）= 6.00。这一发现将有助于该基因的鉴定和PD发病机制的研究。
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Z(max) = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.