Absence of association between reproductive variables and the risk of breast cancer in young women in Sweden and Norway.
Absence of association between reproductive variables and the risk of breast cancer in young women in Sweden and Norway.
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DOI：
10.1038/bjc.1990.242
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发表时间：
1990-07
影响因子：
8.8
通讯作者：
Meirik, O
中科院分区：
文献类型：
--
作者：
Adami, H O;Bergstrom, R;Lund, E;Meirik, O
瑞典和挪威进行了一项基于人群的病例对照研究，分析 45 岁之前发生的乳腺癌与女性生殖生活的几个不同特征之间可能存在的关联。总共有 422 名（89.2%）符合条件的患者和 527 名（80.6%）符合条件的对照组接受了访谈。在单变量分析中，不同的生育特征（胎次、第一次生育年龄、最后一次生育与诊断之间的年数、母乳喂养持续时间以及人工流产和自然流产的次数）、生育期或排卵期的测量（初潮年龄、初潮与第一次怀孕之间的年数以及月经跨度的估计）以及无排卵周期或不孕症的症状似乎都与乳腺癌无关，或至多微弱相关。对多变量分析中可能的混杂因素进行调整，导致风险估计基本不变，比值比接近统一，并且当以分类或连续形式研究暴露变量时，没有任何显着趋势。我们得出的结论是，生殖因素并不能解释该人群 45 岁之前乳腺癌的发生。
A population-based case-control study was conducted in Sweden and Norway to analyse possible associations between breast cancer occurring before the age of 45 and several different characteristics of the women's reproductive life. A total of 422 (89.2%) of all eligible patients, and 527 (80.6%) of all eligible controls were interviewed. In univariate analyses, different characteristics of child-bearing (parity, age at first birth, years between last birth and diagnosis, duration of breast-feeding, and number of induced and spontaneous abortions), measures of the fertile or ovulating period (age at menarche, years between menarche and first pregnancy, and estimates of the menstruation span) and symptoms of anovulatory cycles or infertility were all seemingly unrelated to, or at most weakly associated with breast cancer. Adjustment for possible confounding factors in multivariate analyses resulted in largely unaltered risk estimates with odds ratios close to unity and without any significant trends when the exposure variables were studied in categorised or in continuous form. We conclude that reproductive factors did not explain the occurrence of breast cancer before the age of 45 in this population.