The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation
The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation
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DOI：
10.1523/jneurosci.0666-05.2005
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发表时间：
2005-04-20
影响因子：
5.3
通讯作者：
Serafin, M
中科院分区：
文献类型：
--
作者：
Grivel, J;Cvetkovic, V;Serafin, M
睡眠不足伴随着一种无法抗拒的睡眠需求的逐渐发展，这种现象的机制仍然难以捉摸。在这里，我们首次在体外确认了这一现象的反映，表明在短短2小时的完全睡眠剥夺后，去甲肾上腺素对促进觉醒的下丘脑/增食欲素神经元的作用从兴奋转变为抑制。我们认为，如此明显的反应性改变应该有助于伴随睡眠剥夺而来的越来越多的嗜睡。
Sleep deprivation is accompanied by the progressive development of an irresistible need to sleep, a phenomenon whose mechanism has remained elusive. Here, we identified for the first time a reflection of that phenomenon in vitro by showing that, after a short 2 h period of total sleep deprivation, the action of noradrenaline on the wake-promoting hypocretin/orexin neurons changes from an excitation to an inhibition. We propose that such a conspicuous modification of responsiveness should contribute to the growing sleepiness that accompanies sleep deprivation.