Mother-fetus transference of lead and cadmium in rats: involvement of metallothionein
Mother-fetus transference of lead and cadmium in rats: involvement of metallothionein
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DOI：
10.14670/hh-24.1523
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发表时间：
2009-12-01
影响因子：
2
通讯作者：
Rios, C.
中科院分区：
文献类型：
--
作者：
Benitez, M. A.;Mendez-Armenta, M.;Rios, C.
本研究旨在探讨孕期镉、铅暴露对大鼠的影响及其与金属硫蛋白的关系。大鼠在孕期通过饮水暴露于10ppm的Cd或300ppm的铅。研究人员测量了胎盘、胎儿脑、胎儿和母体血液中这两种金属的含量。用免疫组织化学方法检测胎盘和胎脑中MT的表达。研究发现，染镉组的子代体重明显低于对照组。接触组胎盘中Cd含量增加伴随MT的诱导，这些效应与Cd在胎脑中的有限积累有关。相反，母铅暴露会导致铅在胎儿大脑中的蓄积，并对胎盘造成损害。这一结果解释了这些金属在怀孕期间的转移差异，这可能与它们的毒性有关。
This study was designed to assess the effect of Cadmium (Cd) and lead (Pb) exposure during pregnancy in rats and their correlation with metallothionein (MT). Rats were exposed to either 10 ppm Cd or 300 ppm Pb through drinking water during pregnancy. Both metals were measured in placenta, fetus brain and fetal and maternal blood. MT was quantified in placenta and fetus brain and it was also observed in placenta by immunohistochemical technique. Offspring weight was found to be significantly lower for the Cd exposure group than for the control group. A Cd increase in the placenta of the exposed group was accompanied by MT induction; these effects were related to a limited accumulation of Cd in fetus brain. In contrast, dam Pb exposure caused an accumulation of Pb in the fetus brain and induced damage to placenta. The results account for differences in the transference of these metals during pregnancy that could be related to their toxicity.