Novel Anodization Technique Using a Block Copolymer Template for Nanopatterning of Titanium Implant Surfaces
Novel Anodization Technique Using a Block Copolymer Template for Nanopatterning of Titanium Implant Surfaces
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DOI：
10.1021/am301987e
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发表时间：
2012-11-01
影响因子：
9.5
通讯作者：
Su, Bo
中科院分区：
文献类型：
--
作者：
Sjoestroem, Terje;McNamara, Laura E.;Su, Bo
精确的表面纳米图案化是生物医学材料上细胞行为可预测控制的一种有前途的途径。目前，在将这种精密工程表面从实验室应用于临床相关的植入材料如钛（Ti）方面存在差距。在这项工作中，钛表面的阳极氧化与嵌段共聚物模板相结合，以创建高度有序和可调的氧化物纳米粒子。二次离子质谱（西姆斯）和X射线光电子能谱（XPS）分析表明，阳极氧化结构的组成主要是二氧化钛与少量的氮从嵌段共聚物。进一步证明，这些纳米颗粒可以使用相同的技术叠加在更复杂形状的Ti表面上，例如微珠。将人骨髓间充质干细胞培养在钛微珠表面，有和没有纳米粒子，在体外研究纳米形貌对钛表面的影响。在这项工作中提出的结果表明，一个有前途的方法，生产高度定义和良好排列的表面纳米钛植入物表面。
Precise surface nanopatterning is a promising route for predictable control of cellular behavior on biomedical materials. There is currently a gap in taking such precision engineered surfaces from the laboratory to clinically relevant implant materials such as titanium (Ti). In this work, anodization of Ti surfaces was performed in combination with block copolymer templates to create highly ordered and tunable oxide nanopatterns. Secondary ion mass spectroscopy (SIMS) and X-ray photoelectron spectroscopy (XPS) analyses showed that the composition of the anodized structures was mainly titania with small amounts of nitrogen left from the block copolymer. It was further demonstrated that these nanopatterns can be superimposed on more complex shaped Ti surfaces such as microbeads, using the same technique. Human mesenchymal stem cells were cultured on Ti microbead surfaces, with and without nanopatterns, in vitro to study the effect of nanotopography on Ti surfaces. The results presented in this work demonstrate a promising method of producing highly defined and well-arranged surface nanopatterns on Ti implant surfaces.