Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease
Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease
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DOI：
10.1001/archinte.161.3.361
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发表时间：
2001-02-12
影响因子：
--
通讯作者：
Gyntelberg, F
中科院分区：
文献类型：
--
作者：
Jeppesen, J;Hein, HO;Gyntelberg, F
背景：高甘油三酯-低高密度脂蛋白胆固醇水平(甘油三酯大于或等于1.60 mmol/L[大于或等于142 mg/dL]和高密度脂蛋白小于或等于1.18 mmol/L[小于或等于46 mg/dL])与缺血性心脏病的高风险有关，而低甘油三酯-高密度脂蛋白胆固醇水平(甘油三酯小于或等于1.09[小于或等于97 mg/dL]和高密度脂蛋白胆固醇大于或等于1.48 mmol/L[大于或等于57 mg/dL])与低风险相关。常规危险因素往往与高甘油三酯-低高密度脂蛋白胆固醇水平并存。我们检验了这样的假设，即具有传统危险因素的受试者，如果他们有低甘油三酯-高高密度脂蛋白胆固醇水平，他们患II-ID的风险仍然很低。方法：对2906名年龄在53岁到74岁之间的男性进行了观察性队列研究。结果：在8年中，229名受试者发生了IHD。按常规危险因素分层--低密度脂蛋白胆固醇水平(小于或等于4.40 mmol/L或；4.40 mmol/L[小于或等于70 mg/dL或<170 mg/dL][中位数])、高血压状况(血压150/100 mm Hg或正在服药)、体力活动水平(<4小时/周k)和吸烟状况(非吸烟者与吸烟者)，高TG-低高密度脂蛋白-C水平男性的发病率为9.8%；低危人群为1%~12.2%，高危人群为12.2%~16.4%，低甘油三酯-高密度脂蛋白胆固醇分别为4.0%~5.1%和3.7%~5.3%。根据归因风险估计，如果所有受试者都有低甘油三酯-高高密度脂蛋白胆固醇水平，35%的IHD可能已经被预防。结论：具有IHD传统危险因素的男性，如果他们有低甘油三酯-高高密度脂蛋白胆固醇水平，他们患IHD的风险较低。
Background: A high triglyceride (TG)-low high-density lipoprotein cholesterol (HDL-C) level (TG greater than or equal to1.60 mmol/L [greater than or equal to 142 mg/dL] and HDL-C less than or equal to1.18 mmol/L [less than or equal to 46 mg/dL]) is associated with a high risk of ischemic heart disease (IHD), whereas a low TG-high HDL-C level (TG less than or equal to1.09 [less than or equal to 97 mg/dL] and HDL-C greater than or equal to1.48 mmol/L [greater than or equal to 57 mg/dL]) is associated with a low risk. Conventional risk factors tend to coexist with high TG-low HDL-C levels. We tested the hypothesis that subjects with conventional risk factors would still have a low risk of II-ID if they had low TG-high HDL-C levels.Methods: Observational cohort study of 2906 men aged 53 to 74 years free of IHD at baseline.Results: During 8 years, 229 subjects developed IHD. Stratified by conventional risk factors-low-density lipoprotein cholesterol level (less than or equal to4.40 mmol/L or >4.40 mmol/L [less than or equal to 70 mg/dL or >170 mg/dL] [median value]), hypertensive status (blood pressure >150/100 mm Hg or taking medication), level of physical activity (>4 h/wk or less than or equal to4 h/wk), and smoking status (nonsmokers vs smokers)-the incidence in men with high TG-low HDL-C levels was 9.8%;1 to 12.2% in the low-risk and 12.2% to 16.4% in the high-risk strata; the corresponding values in men with low TG-high HDL-C concentrations were 4.0% to 5.1% and 3.7% to 5.3%, respectively. Based on an estimate of attributable risk, 35% of IHD might have been prevented if all subjects had had low TG-high HDL-C levels.Conclusion: Men with conventional risk factors for IHD have a low risk of IHD if they have low TG-high HDL-C levels.