Turner syndrome and autoimmune diseases: record-linkage study
Turner syndrome and autoimmune diseases: record-linkage study
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DOI：
10.1136/archdischild-2013-304617
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发表时间：
2014-01-01
影响因子：
5.2
通讯作者：
Seminog, Olena O.
中科院分区：
文献类型：
--
作者：
Goldacre, Michael J.;Seminog, Olena O.
背景 越来越多的证据表明特纳综合征与一系列自身免疫性疾病的风险升高有关。我们的目的是在一项全国性研究中记录这一点。 方法 使用 1999 年至 2011 年英格兰所有住院患者的记录关联数据集来构建特纳综合征患者的回顾性队列和非特纳综合征患者的对照队列。统计随访以确定每个队列中 29 种独立自身免疫性疾病的发生情况。计算比率，比较特纳和对照队列。结果 在特纳综合征队列（2459 人）中，29 种病症中有 16 种的比率升高。例子包括乳糜泻（比率14.0，95% CI 10.2至18.8）、克罗恩病（5.3、3.5至7.8）、溃疡性结肠炎（3.9、2.3至6.1）、甲状腺功能减退症（8.8、7.8至9.9）和甲状腺功能亢进（4.9、3.2至7.1）。结论特纳综合征患者患自身免疫性疾病的风险涉及多种疾病。
Background There is increasing evidence that Turner syndrome is associated with an elevated risk of a range of autoimmune disorders. We aimed to document this in a national study.Method Use of a record-linked dataset of all hospital admissions in England, 1999-2011, to construct a retrospective cohort of people with Turner syndrome and a control cohort of people without it. Statistical follow-up to identify the occurrence of 29 separate autoimmune disorders in each cohort. Calculation of rate ratios, comparing the Turner and control cohorts.Results In the Turner syndrome cohort (2459 people), rate ratios were elevated for 16 of the 29 conditions. Examples included coeliac disease (rate ratio 14.0, 95% CI 10.2 to 18.8), Crohn's disease (5.3, 3.5 to 7.8), ulcerative colitis (3.9, 2.3 to 6.1), hypothyroidism (8.8, 7.8 to 9.9) and hyperthyroidism (4.9, 3.2 to 7.1).Conclusions The increased risk of autoimmune disorders in people with Turner syndrome covers a wide range of conditions.