Experimental tricyclic antidepressant toxicity: A randomized, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation
Experimental tricyclic antidepressant toxicity: A randomized, controlled comparison of hypertonic saline solution, sodium bicarbonate, and hyperventilation
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DOI：
10.1016/s0196-0644(98)70009-5
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发表时间：
1998-09-01
影响因子：
6.2
通讯作者：
Fata, J
中科院分区：
文献类型：
--
作者：
McCabe, JL;Cobaugh, DJ;Fata, J
研究目的：在猪模型上比较高渗氯化钠溶液(HTS)、碳酸氢钠溶液(HV)和过度换气(HV)对三环类抗抑郁药(TCA)严重毒性的影响。方法：24头家猪，雌雄不拘，静脉滴注去甲替林(NT)，直至出现QRS持续时间大于120ms且收缩压(SBP)小于或等于50 mm Hg的情况。动物随机分为4组，每组1只。达到毒性时，对照组给予5%葡萄糖水溶液(D5W)10mL/kg，HTS组给予7.5%氯化钠溶液10mL/kg(15mEq Na+/kg)，NaHCO3组给予8.4%碳酸氢钠溶液3mEq/kg，然后给予相当于总体积10mEq/kg的D5W溶液；结果：治疗10min后，对照组平均SEP为54+/-18 mm Hg，HTS组为134+/-21 mm Hg，NaHCO3组为85+/-19 mm Hg，HV组为60+/-12 mm Hg(P
Study objective: We sought to compare the effects of hypertonic sodium chloride solution (HTS), sodium bicarbonate solution, and hyperventilation (HV) on severe tricyclic antidepressant (TCA) toxicity in a swine model.Methods: Twenty-four mixed-breed, domestic swine of either sex were given an intravenous infusion of nortriptyline (NT) until development of both a QRS duration longer than 120 ms and a systolic blood pressure (SBP) less than or equal to 50 mm Hg. Animals were randomly assigned to 1 of 4 groups. On reaching toxicity, the control group received 10 mL/kg of 5% dextrose in water (D5W); the HTS group received 10 mL/kg of 7.5% NaCl solution (15 mEq Na+/kg); the NaHCO3 group received 3 mEq/kg of 8.4% sodium bicarbonate solution followed by enough D5W solution to equal 10 mL/kg of total volume; and the HV group was mechanically hyperventilated to maintain arterial pH between 7.50 and 7.60 and given 10 mL/kg of D5W.Results: The mean SEP 10 minutes after treatment was 54+/-18 mm Hg in the control group, 134+/-21 mm Hg in the HTS group, 85+/-19 mm Hg in the NaHCO3 group, and 60+/-12 mm Hg in the HV group (P