Understanding and preventing agglomeration in a filter drying process
Understanding and preventing agglomeration in a filter drying process
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DOI：
10.1016/j.powtec.2016.03.003
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发表时间：
2016-10-01
影响因子：
5.2
通讯作者：
Haig, Brian
中科院分区：
文献类型：
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作者：
Lim, Hong Lee;Hapgood, Karen P.;Haig, Brian
过滤干燥过程中发生严重团聚是制药行业的一个具有挑战性的问题，目前尚未得到充分理解。产品降解、干燥时间延长、消除结块所需的额外设备以及下游加工问题是这种现象引起的一些问题，来自各个行业的研究人员对探索过滤/干燥加工步骤如何影响粉末的团聚非常感兴趣。本文研究了干燥温度、搅拌速度、填充体积和排污时间等操作条件对大团聚体形成的影响。此外，还探讨了其他潜在的团聚来源，例如冷凝物的滴落以及洗涤溶剂的表面张力。使用碳酸氢钠、碳酸钙和具有高团聚倾向的API中间体进行了一系列系统的实验工作，以了解不同类型粉末之间的团聚行为。研究发现，不同类型粉末的团块形成可能观察到类似的趋势，但团聚的潜在机制不同。每种粉末的独特行为表明，消除团聚物形成的通用解决方案或缓解方法可能是不可能的。然而，通过识别粉末-溶剂系统中存在的特定团聚机制，可以以更有效的方式进行缓解，以最大限度地减少团聚。 (C) 2016 Elsevier B.V. 保留所有权利。
The occurrence of severe agglomeration during a filter drying process is a challenging issue in the pharmaceutical industry and has yet to be fully understood. Product degradation, extended drying times, additional equipment required for the elimination of lumps and downstream processing issues are some of the problems caused by this phenomenon and there is great interest among researchers from various industries to explore how the filtration/drying processing step impacts the agglomeration of powder. This paper investigates the effect of operating condition such as the drying temperature, agitation speed, fill volume and blow-down period on the formation of large agglomerates. In addition, other potential sources of agglomeration such as the dripping of condensates as well as surface tension of wash solvents were also explored. A series of systematic experimental work was carried out using sodium bicarbonate, calcium carbonate and an API intermediate which has high agglomeration tendency to understand behaviour of agglomeration among the different types of powder. It was found that similar trends may be observed in the formation of lumps for different types of powders but the underlying mechanisms of agglomeration were different. The unique behaviour of each powder suggested that a universal solution or mitigation method to eliminate the formation of agglomerate may not be possible. However, by identifying the specific agglomeration mechanisms present in a powder-solvent system, it is possible to carry out the mitigation in a more effective way to minimize the agglomeration. (C) 2016 Elsevier B.V. All rights reserved.