SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.
SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.
复制标题
DOI：
10.1126/science.1193036
复制
发表时间：
2010-10-22
期刊：
影响因子：
--
通讯作者：
Muskavitch MAT
中科院分区：
文献类型：
--
作者：
Neafsey DE;Lawniczak MKN;Park DJ;Redmond SN;Coulibaly MB;Traoré SF;Sagnon N;Costantini C;Johnson C;Wiegand RC;Collins FH;Lander ES;Wirth DF;Kafatos FC;Besansky NJ;Christophides GK;Muskavitch MAT
冈比亚按蚊复合群中的蚊子表现出快速的生态和行为多样化，这些特征促进了疟疾传播，并使病媒控制工作复杂化。一个高密度，全基因组蚊子SNP基因分型阵列允许映射种群和物种之间的基因组分化，表现出不同程度的生殖隔离。着丝粒附近或多态倒位内的区域表现出最大的遗传分歧，但在基因组的其他地方也观察到分歧。种群内的自然选择信号在种群间分化的基因组区域中被过度表达，这意味着分化往往是由种群特异性选择事件驱动的。物种形成媒介蚊子种群之间复杂的基因组差异意味着，全基因组监测种群结构的工具将证明对促进消灭疟疾是有用的。
Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.