Preparing for future efficacy trials of severe malaria vaccines.
Preparing for future efficacy trials of severe malaria vaccines.
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为未来重症疟疾疫苗的功效试验做准备。
DOI：
10.1016/j.vaccine.2016.02.053
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发表时间：
2016
期刊：
影响因子：
5.5
通讯作者：
Duffy,PatrickE
中科院分区：
文献类型：
--
作者：
Gonçalves,BronnerP;Prevots,DRebecca;Kabyemela,Edward;Fried,Michal;Duffy,PatrickE
严重疟疾是儿童死亡的一个主要原因，但在自然接触人群中，恶性疟原虫感染只占一小部分。对预防严重恶性疟原虫病的疫苗的评价将需要临床试验，其主要疗效终点将是随访期间的严重疟疾风险。在这里，我们表明，在严重疟疾发病率达到高峰的年龄段，在疟疾传播严重的地区，这种试验是可行的，参与者不到1000人。
Severe malaria is a major cause of mortality in children, but comprises only a small proportion of Plasmodium falciparum infections in naturally exposed populations. The evaluation of vaccines that prevent severe falciparum disease will require clinical trials whose primary efficacy endpoint will be severe malaria risk during follow-up. Here, we show that such trials are feasible with fewer than 1000 participants in areas with intense malaria transmission during the age interval when severe malaria incidence peaks.