Temperature sensation in Drosophila.
Temperature sensation in Drosophila.
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DOI：
10.1016/j.conb.2015.01.002
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发表时间：
2015-10
影响因子：
5.7
通讯作者：
Garrity PA
中科院分区：
文献类型：
--
作者：
Barbagallo B;Garrity PA
动物利用温度感应系统来达到生长和繁殖的最佳温度，并避免破坏性的极端温度。体温调节对于果蝇等小型动物来说尤其具有挑战性，它们的体温会随着环境温度的波动而迅速变化。最近的工作已经发现了一些介导苍蝇温度感觉的关键分子，包括瞬时受体电位（TRP）通道TRPA1和无痛，以及味觉受体Gr28b，一种通常与不同感觉方式相关的意外温度感觉调节器。也有证据表明，果蝇的光转导级联可能在热敏反应中发挥一定作用。苍蝇的各种热感觉分子共同作用于一系列功能不同的热感觉神经元，以驱动一套复杂的，通常是特别敏感的行为。
Animals use thermosensory systems to achieve optimal temperatures for growth and reproduction and to avoid damaging extremes. Thermoregulation is particularly challenging for small animals like the fruit fly Drosophila melanogaster, whose body temperature rapidly changes in response to environmental temperature fluctuation. Recent work has uncovered some of the key molecules mediating fly thermosensation, including the Transient Receptor Potential (TRP) channels TRPA1 and Painless, and the Gustatory Receptor Gr28b, an unanticipated thermosensory regulator normally associated with a different sensory modality. There is also evidence the Drosophila phototransduction cascade may have some role in thermosensory responses. Together, the fly’s diverse thermosensory molecules act in an array of functionally distinct thermosensory neurons to drive a suite of complex, and often exceptionally thermosensitive, behaviors.