Azide-rich peptides via an on-resin diazotransfer reaction.
Azide-rich peptides via an on-resin diazotransfer reaction.
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DOI：
10.1002/bip.22634
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发表时间：
2015-07
期刊：
影响因子：
2.9
通讯作者：
Rudick JG
中科院分区：
文献类型：
--
作者：
Marine JE;Liang X;Song S;Rudick JG
含叠氮化物的氨基酸在肽化学中是有价值的构建块，因为叠氮化物在几个生物正交反应中是稳健的伙伴。在固相肽合成中，用非极性的含叠氮化物的氨基酸代替极性氨基酸可能是棘手的，特别是当要在氨基酸序列中引入多个叠氮化物残基时。我们提出了一种策略，有效地将多个含叠氮化物的残基位点特异性。
Azide-containing amino acids are valuable building blocks in peptide chemistry, because azides are robust partners in several bioorthogonal reactions. Replacing polar amino acids with apolar, azide-containing amino acids in solid-phase peptide synthesis can be tricky, especially when multiple azide residues are to be introduced in the amino acid sequence. We present a strategy for effectively incorporating multiple azide-containing residues site-specifically.