3 PREGNANCY PROTEINS (PP12, PP14, AND PAPP-A) - THEIR BIOLOGICAL AND CLINICAL RELEVANCE
3 PREGNANCY PROTEINS (PP12, PP14, AND PAPP-A) - THEIR BIOLOGICAL AND CLINICAL RELEVANCE
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DOI：
10.1055/s-2007-999559
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发表时间：
1989-04-01
影响因子：
2
通讯作者：
BISCHOF, P
中科院分区：
文献类型：
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作者：
BISCHOF, P
本文综述的三种妊娠蛋白PP12、PP14和PAPP-A都是在孕酮影响下由子宫内膜产生的。它们的产量在分泌期很低，在蜕膜和怀孕后急剧增加。PP12和PP14由上皮细胞合成，PAPP-A由基质细胞合成。PAPP-A的浓度可能反映了基质细胞的相对丰富程度，随着胎龄的增长，PAPP-A的浓度逐渐升高，而PP12和PP14的水平在妊娠20周后趋于平稳，甚至下降。这些蛋白质也在未怀孕的受试者的子宫外部位：卵泡、卵泡液、黄体细胞和输卵管中发现，在男性的精囊和精液中也发现。PP12已经在几种形式的癌症中被发现，尽管频率还不足以使其成为有用的肿瘤标记物。这些蛋白的生物学功能仍有待推测，但它们确实反映了蜕膜子宫内膜的生物合成能力，特别是PP14可能会在不孕症患者的治疗中得到临床应用。
The three pregnancy proteins, PP12, PP14, and PAPP-A, reviewed here are all produced by the endometrium under the influence of progesterone. Their production is low during the secretory phase and increases dramatically after decidualization and pregnancy. PP12 and PP14 are synthesized by the epithelial cells and PAPP-A is synthesized by the stromal cells. Reflecting perhaps the relative abundance of stromal cells, PAPP-A concentrations increase progressively to term, whereas the levels of PP12 and PP14 level off and even decline after the 20th week of gestation. These proteins are also found in nonpregnant subjects in extrauterine sites: follicles, follicular fluid, luteal cells, and fallopian tubes, and in males, in seminal vesicles and seminal fluid. PP12 has been found in several forms of cancer, although not with sufficient frequency to make it a useful tumor marker. The biologic function of these proteins is still subject to speculation, but they do reflect the biosynthetic capacity of decidualized endometrium, and especially PP14 may find clinical application in the management of infertility patients.