Maternal stress and the maternal microbiome have sex-specific effects on offspring development and aggressive behavior in Siberian hamsters (Phodopus sungorus)
Maternal stress and the maternal microbiome have sex-specific effects on offspring development and aggressive behavior in Siberian hamsters (Phodopus sungorus)
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DOI：
10.1016/j.yhbeh.2022.105146
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发表时间：
2022-03-08
影响因子：
3.5
通讯作者：
Demas, Gregory E.
中科院分区：
文献类型：
--
作者：
Cusick, Jessica A.;Wellman, Cara L.;Demas, Gregory E.
肠道微生物组是一个由共生、共生和致病细菌、真菌和病毒组成的群落，与许多生理系统相互作用以影响行为。产前经历，包括暴露于母亲压力和不同的母亲微生物组，是影响后代发育的有机体变异的重要来源。这些生理系统并不是孤立地发挥作用，会对后代的发育和行为产生长期影响。在这里，我们使用西伯利亚仓鼠（Phodopus sungorus）研究了母体压力和母体微生物组操纵对后代发育和社会行为的相互作用影响。我们让怀孕的女性在怀孕期间暴露于社会压力源、抗生素、社会压力源和抗生素，或者不接受治疗（即控制），并量化男性和女性后代的生长、肠道微生物组的组成和多样性、压力诱导的皮质醇浓度和社会行为。母体抗生素暴露改变了雄性和雌性后代的肠道微生物群落。母亲的治疗对后代的发育和攻击行为也有性别特异性的影响。压力大的母亲所生下的雌性后代比其他雌性后代更具攻击性。接受联合治疗的母亲所产下的女性（而非男性）后代表现出较低水平的攻击性，这表明母体微生物组的改变以性别特异性的方式减弱了产前应激的影响。母亲的治疗并不影响后代的非攻击性行为。总的来说，我们的研究深入了解了母体系统如何相互作用，以特定性别的方式影响后代，并强调了母体微生物组在调节后代发育和行为中的重要作用。
The gut microbiome, a community of commensal, symbiotic and pathogenic bacteria, fungi, and viruses, interacts with many physiological systems to affect behavior. Prenatal experiences, including exposure to maternal stress and different maternal microbiomes, are important sources of organismal variation that can affect offspring development. These physiological systems do not act in isolation and can have long-term effects on offspring development and behavior. Here we investigated the interactive effects of maternal stress and manipulations of the maternal microbiome on offspring development and social behavior using Siberian hamsters, Phodopus sungorus. We exposed pregnant females to either a social stressor, antibiotics, both the social stressor and antibiotics, or no treatment (i.e., control) over the duration of their pregnancy and quantified male and female offspring growth, gut microbiome composition and diversity, stress-induced cortisol concentrations, and social behavior. Maternal antibiotic exposure altered the gut microbial communities of male and female offspring. Maternal treatment also had sex-specific effects on aspects of offspring development and aggressive behavior. Female offspring produced by stressed mothers were more aggressive than other female offspring. Female, but not male, offspring produced by mothers exposed to the combined treatment displayed low levels of aggression, suggesting that alteration of the maternal microbiome attenuated the effects of prenatal stress in a sex-specific manner. Maternal treatment did not affect non-aggressive behavior in offspring. Collectively, our study offers insight into how maternal systems can interact to affect offspring in sex-specific ways and highlights the important role of the maternal microbiome in mediating offspring development and behavior.