Correlates of fatigue in HIV infection prior to AIDS: A pilot study
Correlates of fatigue in HIV infection prior to AIDS: A pilot study
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DOI：
10.3109/09638289609166309
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发表时间：
1996-05-01
影响因子：
2.2
通讯作者：
Riggs, RV
中科院分区：
文献类型：
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作者：
ODell, MW;Meighen, M;Riggs, RV
疲劳被广泛认为是人类免疫缺陷病毒(HIV)感染者发病的一个重要来源，但很少有数据研究这一人群中的疲劳。我们提供了评估疲劳感与各种生理和心理社会措施之间关系的先导性数据，这些患者在获得性免疫缺陷综合征(AIDS)的临床发展之前，有20名男性HIV感染者。采用视觉模拟评定量表(VAS)和疲劳评定量表(FAI)测量疲劳程度。在疲劳程度和身体参数之间没有发现有统计学意义的关联，包括血红蛋白、红细胞压积、白蛋白、总蛋白和疾病影响概况(SIP)的身体维度分数。家庭暴力指数与贝克抑郁量表和心理社会维度相关良好(r分别为0.72和0.81；p<；0.001)。FAI和VAS都与SIP总分有中等程度的关联。先前报道，在慢性疲劳但没有感染艾滋病毒的人群样本中观察到的SIP特征与观察到的相似。尽管样本量很小，但我们的数据表明，艾滋病毒感染者和疲劳者中的心理社会参数比身体参数有更强的相关性。对临床管理和进一步研究的意义进行了讨论。
Fatigue is widely recognized as a significant source of morbidity in persons with human immunodeficiency virus (HIV) infection, yet there are few data examining fatigue in this population. We present pilot data assessing the relationship between fatigue and various physical and psychosocial measures in 20 men with HIV infection prior to the clinical development of acquired immunodeficiency syndrome (AIDS). Fatigue was measured by a visual analogue scale (VAS) and the Fatigue Assessment Inventory (FAI). No statistically significant associations were found between fatigue measures and physical parameters including haemoglobin, haematocrit, albumin, total protein, and physical dimension score of the Sickness Impact Profile (SIP). The FAI correlated well with Beck's Depression Inventory and SIP - Psychosocial Dimension (r = 0.72 and 0.81, respectively; p < 0.001.) Both the FAI and VAS held moderate associations with the total SIP score. The SIP profile was similar to that observed in a sample of persons with chronic fatigue but without HIV infection, reported previously. Although the sample size is small, our data suggest a stronger association with psychosocial, rather than physical, parameters among persons with HIV infection and fatigue. The implications for clinical management and further research are discussed.