SPECIFIC TYPES OF COLONIC FERMENTATION MAY RAISE LOW-DENSITY-LIPOPROTEIN-CHOLESTEROL CONCENTRATIONS
SPECIFIC TYPES OF COLONIC FERMENTATION MAY RAISE LOW-DENSITY-LIPOPROTEIN-CHOLESTEROL CONCENTRATIONS
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DOI：
10.1093/ajcn/54.1.141
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发表时间：
1991-07-01
影响因子：
7.1
通讯作者：
PATTEN, R
中科院分区：
文献类型：
--
作者：
JENKINS, DJA;WOLEVER, TMS;PATTEN, R
为了评估增加的结肠发酵对血脂的影响，8名健康志愿者被安排在两种相同的2周代谢饮食中，其中一种补充乳果糖（18-25 g/d）。乳果糖使呼气氢浓度和血清谷氨酰胺浓度分别提高了78 +/- 13% （P < 0.001）和24.7 +/- 9.5% （P < 0.05）。然而，出乎意料的是，与对照组相比，空腹血清总胆固醇、低密度脂蛋白胆固醇和载脂蛋白B浓度在2周时分别升高了8.9 +/- 1.5% （P < 0.001）、10.9 +/- 2.2% （P < 0.005）和18.9 +/- 5.9% （P < 0.02）。使用乳果糖，平均游离脂肪酸浓度在一天内降低了19.5 +/- 5.9% (P < 0.02)，而平均全天血糖、血清胰岛素或c肽浓度没有变化。我们得出结论，某些快速发酵的底物可能提高而不是降低血脂，可能是通过增加从结肠吸收的乙酸的量。
To assess the effects of increased colonic fermentation on serum lipids, eight healthy volunteers were placed on two identical 2-wk metabolic diets, one of which was supplemented with lactulose (18-25 g/d). Lactulose raised day-long concentrations of breath hydrogen and serum glutamine as indicators of increased colonic fermentation by 78 +/- 13% (P < 0.001) and 24.7 +/- 9.5% (P < 0.05), respectively). Unexpectedly, however, fasting serum total and low-density-lipoprotein cholesterol and apolipoprotein B concentrations were higher at 2 wk by 8.9 +/- 1.5% (P < 0.001), 10.9 +/- 2.2% (P < 0.005), and 18.9 +/- 5.9% (P < 0.02), respectively, compared with the control diet. With lactulose, mean free fatty acid concentrations were reduced over the day by 19.5 +/- 5.9% (P < 0.02), with no change in mean day-long blood glucose, serum insulin, or C-peptide concentrations. We conclude that certain rapidly fermented substrates may raise rather than lower serum lipids, possibly through increasing the amount of acetate absorbed from the colon.