Optically Responsive, Smart Anti-Bacterial Coatings via the Photofluidization of Azobenzenes
Optically Responsive, Smart Anti-Bacterial Coatings via the Photofluidization of Azobenzenes
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DOI：
10.1021/acsami.8b21058
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发表时间：
2019-01-16
影响因子：
9.5
通讯作者：
Nair, Devatha P.
中科院分区：
文献类型：
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作者：
Kehe, Gannon M.;Mori, Dylan I.;Nair, Devatha P.
由于耐抗生素细菌的增加，抗菌药物作为一种抑制表面生物膜形成和生长的机制最近引起了人们的极大兴趣。基于偶氮苯的光流化，我们首次展示了通过光机械激活生物膜的破坏和分散，使细菌生物膜减少4倍的能力。这种使生物膜去除的独特策略为对抗抗生素耐药性提供了一种新的范例。
Antibacterial strategies sans antibiotic drugs have recently garnered much interest as a mechanism by which to inhibit biofilm formation and growth on surfaces due to the rise of antibiotic-resistant bacteria. Based on the photofluidization of azobenzenes, we demonstrate for the first time the ability achieve up to a 4 log reduction in bacterial biofilms by opto-mechanically activating the disruption and dispersion of biofilms. This unique strategy with which to enable biofilm removal offers a novel paradigm with which to combat antibiotic resistance.