White matter abnormalities in the fornix are linked to cognitive performance in SZ but not in BD disorder: An exploratory analysis with DTI deterministic tractography
White matter abnormalities in the fornix are linked to cognitive performance in SZ but not in BD disorder: An exploratory analysis with DTI deterministic tractography
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DOI：
10.1016/j.jad.2016.03.015
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发表时间：
2016-09-01
影响因子：
6.6
通讯作者：
Oertel-Knoehel, Viola
中科院分区：
文献类型：
--
作者：
Knoechel, Christian;Schmied, Claudia;Oertel-Knoehel, Viola
背景：在精神病患者中，已经检测到白质(WM)微结构的改变；然而，在双相(BD)和精神分裂症(SZ)患者之间直接比较所发现的结果是很少的。方法：应用弥散张量成像(DTI)对32例良性BD患者、26例SZ患者和30例健康对照进行弥散张量成像(DTI)。应用多项扩散指数(分数各向异性(FA)、束体积(Vol)、束长度(Le)和束数目(NOIR))对双侧穹隆、扣带、丘脑前部和穹隆进行确定性纤维束成像。穹隆纤维追踪评分与SZ患者的认知表现有关，在BD患者组中与年龄和发病年龄相关。限制：尽管在SZ和BD患者中，精神药物作为偏向变量对形态改变的影响已经讨论过，但我们没有观察到药物暴露对我们的发现的明显影响。结论：这些结果证实了SZ患者比BD患者有更严重的WM变化的假设。研究结果还表明穹隆的WM改变作为重要的额缘连接在SZ认知症状的病因中起主要作用，而在BD中则不是。(C)2016爱思唯尔B.V.保留所有权利。
Background: In psychosis, white matter (WM) microstructural changes have been detected previously; however, direct comparisons of findings between bipolar (BD) and schizophrenia (SZ) patients are scarce. In this study, we employed deterministic tractography to reconstruct WM tracts in BD and SZ patients.Methods: Diffusion tensor imaging (DTI) data was carried out with n=32 euthymic BD type I patients, n=26 SZ patients and 30 matched healthy controls. Deterministic tractography using multiple indices of diffusion (fractional anisotropy (FA), tract volume (Vol), tract length (Le) and number of tracts (Noir)) were obtained from the fornix, the cingulum, the anterior thalamic radiation, and the corpus callosum bilaterally.Results: We showed widespread WM microstructural changes in SZ, and changes in the corpus callosum, the left cingulum and the fornix in BD. Fornix fiber tracking scores were associated with cognitive performance in SZ, and with age and age at disease onset in the BD patient group.Limitations: Although the influence of psychopharmacological drugs as biasing variables on morphological alterations has been discussed for SZ and BD, we did not observe a clear influence of drug exposure on our findings.Conclusions: These results confirm the assumption that SZ patients have more severe WM changes than BD patients. The findings also suggest a major role of WM changes in the fornix as important fronto-limbic connections in the etiology of cognitive symptoms in SZ, but not in BD. (C) 2016 Elsevier B.V. All rights reserved.