The Association Between Neutrophil/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis
The Association Between Neutrophil/Lymphocyte Ratio and Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis
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DOI：
10.1002/jcla.21908
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发表时间：
2016-09-01
影响因子：
2.7
通讯作者：
Goker, Berna
中科院分区：
文献类型：
--
作者：
Mercan, Ridvan;Bitik, Berivan;Goker, Berna
背景：在许多情况下，中性粒细胞计数升高与预后不良和死亡率增加相关。中性粒细胞与淋巴细胞比率（NLR）已成为肿瘤和心血管疾病中炎症的标志物。在此，我们调查了这个简单的工具在类风湿性关节炎（RA）和强直性脊柱炎（AS）中的效用。方法：研究包括136例RA和140例AS患者，沿着117例健康对照者。分别采用疾病活动性评分（DAS）和Bath强直性脊柱炎疾病活动性指数（BASDAI）测定RA和AS活性。分析了NLR与疾病活动性之间的关系。结果如下：与健康对照组相比，RA和AS患者的红细胞沉降率（ESR）、C反应蛋白（CRP）和中性粒细胞计数显著升高。同样，RA（2.53 +/- 1.4 vs. 2.16 +/- 1.0，P = 0.019）和AS（2.43 +/- 1.4 vs. 2.16 +/- 1.0，P = 0.077）的NLR高于对照受试者。在RA和AS中，NLR与ESR和CRP均具有良好的相关性。此外，DAS 28活动性恶化组的NLR增加（缓解患者为2.1 +/- 1.0，低-中度患者为2.5 +/- 1.0，高疾病活动性患者为3.8 +/- 2.5）。然而，NLR和BASDAI之间没有发现关联。结论：NLR是一种廉价、易得的评估RA疾病活动性的指标。(C)2015 Wiley Periodicals，Inc.
Background: Elevated neutrophil count is associated with poor prognosis and increased mortality in many conditions. Neutrophil to lymphocyte ratio (NLR) has emerged as a marker of inflammation in neoplastic and cardiovascular disorders. Herein, we investigated utility of this simple tool in rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Methods: The study consisted of 136 RA and 140 AS patients, along with 117 healthy control subjects. RA and AS activities were determined with Disease Activity Score (DAS) and Bath Ankylosing Spondylitis Disease Activity indices (BASDAI), respectively. The association between NLR and disease activity was analyzed. Results: Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and neutrophil counts were significantly higher in RA and AS patients compared to healthy controls. Similarly, NLR was higher compared to control subjects, both in RA (2.53 +/- 1.4 vs. 2.16 +/- 1.0, P = 0.019) and AS (2.43 +/- 1.4 vs. 2.16 +/- 1.0, P = 0.077). NLR correlated well with ESR and CRP, both in RA and AS. Moreover, NLR increased across worsening DAS28 activity groups (2.1 +/- 1.0 in patients with remission, 2.5 +/- 1.0 in low-moderate, 3.8 +/- 2.5 in high disease activity). However, no association was found between NLR and BASDAI. Conclusion: NLR is a cheap and readily available marker for the assessment of disease activity in RA. (C) 2015 Wiley Periodicals, Inc.