RELATIONSHIP BETWEEN GLOMERULAR LESIONS, SERUM CREATININE AND INTERSTITIAL VOLUME IN MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
RELATIONSHIP BETWEEN GLOMERULAR LESIONS, SERUM CREATININE AND INTERSTITIAL VOLUME IN MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS
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DOI：
10.1007/bf01490515
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
BOHLE, A
中科院分区：
文献类型：
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作者：
FISCHBACH, H;MACKENSEN, S;BOHLE, A
对33例不同肾小球受累级别的膜增生性肾小球肾炎患者的形态测量结果显示，肾小球病变的严重程度与血清肌酐水平之间没有一定的关系。另一方面，相对间质体积与血清肌酐水平之间存在显着的正相关性。最佳同余性（r=+ 0, 87，p 小于 0.0001）显示指数函数 y= 0.563-e0。 049x。因此，我们得出结论，在通常被认为是肾小球疾病的膜增殖性肾小球肾炎中，必须考虑间质变化作为肾功能不全的原因。肾小球病变本身不能解释功能障碍。间质体积增加导致肾功能不全的病理生理学因素（可能源于免疫学）尚未完全阐明。
Morphometric investigations in 33 patients suffering from membranoproliferative glomerulonephritis at different grades of glomerular involvement showed that there is no certain relationship between the severity of glomerular lesions and the serum creatinine level. On the other hand there is a significant positive correlation between the relative interstitial volume and the level of serum creatinine. The best congruence (r=+ 0, 87, p less than 0.0001) showed an exponential function y= 0.563-e0. 049x. We therefore conclude that in membranoproliferative glomerulonephritis which is generally considered to be a glomerular disease, interstitial changes have to be taken into account as a cause of renal insufficiency. Glomerular lesions alone cannot explain the functional impairment. The pathophysiologic factors concerning increased interstitial volume as a cause of renal insufficiency-probably immunologic in origin-are yet to be completely clarified.