Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson's disease
Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson's disease
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DOI：
10.1093/brain/awab236
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发表时间：
2021-07-01
期刊：
影响因子：
14.5
通讯作者：
Sommerauer, Michael
中科院分区：
文献类型：
--
作者：
Doppler, Christopher E. J.;Kinnerup, Martin B.;Sommerauer, Michael
先前的研究已经报道了去甲肾上腺素能系统在帕金森病中的大量参与。神经黑素敏感的MRI序列和PET示踪剂已成为可视化的蓝斑和去甲肾上腺素能终端transporters.Combining这些方法的密度的细胞体，我们研究了在帕金森氏病的这些不同的车厢神经退行性变的关系。我们检查了93名受试者（40名健康对照者和53名帕金森病患者）的神经黑素敏感的涡轮自旋回波MRI和计算蓝斑到脑桥的信号对比。从已发表的蓝斑坐标中提取具有最高强度的体素，并将其转换为个体MRI。为了研究蓝斑变性的潜在空间模式，我们从蓝斑的吻侧、中部和尾侧三分之一提取了最高信号强度。此外，创建了研究特定的蓝斑概率图，并用于提取整个蓝斑和每个吻尾细分的平均MRI对比度。采用手动分割法测量蓝斑体积，73名受试者接受C-11-MeNER PET测定去甲肾上腺素转运蛋白密度，计算去甲肾上腺素转运蛋白富集区的分布体积比。帕金森病患者显示蓝斑MRI对比度降低，与所选方法无关（体素方法：P
Previous studies have reported substantial involvement of the noradrenergic system in Parkinson's disease. Neuromelanin-sensitive MRI sequences and PET tracers have become available to visualize the cell bodies in the locus coeruleus and the density of noradrenergic terminal transporters.Combining these methods, we investigated the relationship of neurodegeneration in these distinct compartments in Parkinson's disease. We examined 93 subjects (40 healthy controls and 53 Parkinson's disease patients) with neuromelanin-sensitive turbo spin-echo MRI and calculated locus coeruleus-to-pons signal contrasts. Voxels with the highest intensities were extracted from published locus coeruleus coordinates transformed to individual MRI. To also investigate a potential spatial pattern of locus coeruleus degeneration, we extracted the highest signal intensities from the rostral, middle, and caudal third of the locus coeruleus. Additionally, a study-specific probabilistic map of the locus coeruleus was created and used to extract mean MRI contrast from the entire locus coeruleus and each rostro-caudal subdivision. Locus coeruleus volumes were measured using manual segmentations.A subset of 73 subjects had C-11-MeNER PET to determine noradrenaline transporter density, and distribution volume ratios of noradrenaline transporter-rich regions were computed. Patients with Parkinson's disease showed reduced locus coeruleus MRI contrast independently of the selected method (voxel approaches: P