Differentiation of hemangioblasts from embryonic mesothelial cells?: A model on the origin of the vertebrate cardiovascular system
Differentiation of hemangioblasts from embryonic mesothelial cells?: A model on the origin of the vertebrate cardiovascular system
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DOI：
10.1046/j.1432-0436.1999.6430133.x
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发表时间：
1999-03-01
期刊：
影响因子：
2.9
通讯作者：
González, M
中科院分区：
文献类型：
--
作者：
Muñoz-Chápuli, R;Pérez-Pomares, JM;González, M
成血管细胞是内皮细胞和造血细胞谱系的共同祖细胞，其存在于本世纪初被提出。尽管最近的发现似乎证实了它的存在，但成血管细胞何时以及如何分化仍不清楚。我们提出了关于成血管细胞起源于胚胎内脏间皮的假设。该模型基于从文献和我们自己的研究中收集的观察结果。这些观察结果包括：（1）内皮中胚层的大量间皮衍生细胞与内皮和造血祖细胞的出现同时发生； (2)细胞角蛋白（主要的间皮中间丝蛋白）在一些胚胎血管和内皮祖细胞中的短暂定位； (3) 心血管可能起源于心外膜来源的细胞； (4)当内脏中胚层是上皮时，心内膜细胞起源于内脏中胚层； (5)间皮细胞迁移至背主动脉造血区的证据。 (6)间皮细胞和内皮细胞之间的生化和抗原相似性。我们认为，内皮血管系统是作为系统发育上较古老的体腔的特殊化而出现的。造血细胞的起源可能与一些无脊椎动物中报道的体腔细胞从体腔上皮的分化有关。某些类型的体腔细胞对微生物入侵做出反应，而其他类型的体腔细胞则运输呼吸色素。我们认为这种系统发育起源在脊椎动物个体发育中得到了重述，并解释了内皮细胞和血细胞从共同的间皮衍生祖细胞的分化。
The existence of the hemangioblast, a common progenitor of the endothelial and hematopoietic cell lineages, was proposed at the beginning of the century. Although recent findings seem to confirm its existence, it is still unknown when and how the hemangioblasts differentiate. We propose a hypothesis about the origin of hemangioblasts from the embryonic splanchnic mesothelium. The model is based on observations collected from the literature and from our own studies. These observations include: (1) the extensive population of the splanchnic mesoderm by mesothelial-derived cells coinciding with the emergence of the endothelial and hematopoietic progenitors; (2) the transient localization of cytokeratin, the main mesothelial intermediate filament protein, in some embryonic vessels and endothelial progenitors; (3) the possible origin of cardiac vessels from epicardial-derived cells; (4) the origin of endocardial cells from the splanchnic mesoderm when this mesoderm is an epithelium; (5) the evidence that mesothelial cells migrate to the hemogenic areas of the dorsal aorta. (6) Biochemical and antigenic similarities between mesothelial and endothelial cells. We suggest that the endothelium-lined vascular system arose as a specialization of the phylogenetically older coelomic cavities. The origin of the hematopoietic cells might be related to the differentiation, reported in some invertebrates, of coelomocytes from the coelomic epithelium. Some types of coelomocytes react against microbial invasion and other types transport respiratory pigments. We propose that this phylogenetic origin is recapitulated in the vertebrate ontogeny and explains the differentiation of endothelial and blood cells from a common mesothelial-derived progenitor.