Epilepsy, antiepileptic drugs (AEDs) and cognition
Epilepsy, antiepileptic drugs (AEDs) and cognition
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DOI：
10.1034/j.1600-0404.108.s180.4.x
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发表时间：
2003-10-01
影响因子：
3.5
通讯作者：
Carreño, M
中科院分区：
文献类型：
--
作者：
Hirsch, E;Schmitz, B;Carreño, M
癫痫患者认知障碍的风险增加。癫痫是由多种因素造成的：癫痫发作本身的影响、心理社会因素和 AED 的不良反应。至关重要的是，在早期诊断出正确的癫痫综合征后，患者应接受适当的药物治疗，因为不正确的 AED 可能会加剧症状。通过讨论各种癫痫综合征并对现有证据进行广泛审查，可以就认知方面的 AED 处方提出建议。该领域的一个有趣的进展是越来越多地使用 AED，例如丙戊酸（在一些国家需要使用双丙戊酸）、卡马西平或拉莫三嗪（拉莫三嗪已在该适应症中获得批准）用于治疗双相情感障碍。儿童和老年人尤其容易受到认知方面的不利影响。该综述强调了丙戊酸在这些人群中的优势；它具有良好的耐受性，并且很少产生认知副作用。
People with epilepsy are at increased riskof cognitive de. cits as a result of various factors: the effect of seizures themselves, psychosocial factors and adverse effects of AEDs. It is crucial that, following early diagnosis of the correct epileptic syndrome, patients are treated with the appropriate drugs, as incorrect AEDs can exacerbate symptoms. By discussing various epileptic syndromes and performing a broad review of the available evidence, it is possible to make recommendations concerning prescription of AEDs with respect to cognition. An interesting advance in this area is the increasing use of AEDs such as valproate (in some countries divalproex is indicated), carbamazepine or lamotrigine (lamotrigine has been. led for approval in this indication) for bipolar disorders. Children and the elderly are especially vulnerable to adverse effects on cognition. This review highlights advantages of valproate in these populations; it is well tolerated and produces few cognitive side effects.