MULTISTEP CARCINOGENESIS IN ANAPLASTIC THYROID CARCINOMA: A CASE REPORT
MULTISTEP CARCINOGENESIS IN ANAPLASTIC THYROID CARCINOMA: A CASE REPORT
复制标题
甲状腺未变性癌的多级癌变：病例报告
DOI：
10.1080/00313020120105732
复制
发表时间：
2002
期刊：
影响因子：
4.5
通讯作者：
Tetsuro Kobayashi
中科院分区：
文献类型：
--
作者：
H. Asakawa;Tetsuro Kobayashi
我们之前建立了一个具有双重突变的未分化甲状腺癌细胞系（KOA 2）：N-ras突变和p53基因突变。为了阐明多步致癌作用，我们分析了来自KOA 2患者的手术材料，以确定N-ras和p53基因的异常。切除的材料有两个组织学上不同的病变：滤泡性肿瘤和未分化癌。在两种病变中均观察到N-ras突变，但p53基因突变仅见于间变性病变。这些事实表明，N-ras突变可能会诱导滤泡性肿瘤，随后的p53突变可能会导致该患者的滤泡性肿瘤转化为间变性癌。本报告提出了甲状腺未分化癌多步骤癌变的直接证据。缩写：APC，腺瘤性结肠息肉病; DCC，结直肠癌缺失; PCR-SSCP，聚合酶链反应-单链构象多态性。
Summary We previously established an anaplastic thyroid carcinoma cell line (KOA2) that had double mutations: an N‐ras mutation and a p53 gene mutation. To clarify multistep carcinogenesis, we analysed surgical material from the patient from whom KOA2 was derived for abnormalities in the N‐ras and p53 genes. The resected material had two histologically different lesions: a follicular neoplasm and an anaplastic carcinoma. The N‐ras mutation was observed in both lesions, but the p53 gene mutation only in the anaplastic lesion. These facts indicate that an N‐ras mutation may induce follicular neoplasm and a subsequent p53 mutation may have caused the follicular neoplasm to transform to anaplastic carcinoma in this patient. This report suggests direct evidence for multistep carcinogenesis in anaplastic thyroid carcinoma.Abbreviations: APC, adenomatous polyposis coli; DCC, deleted in colorectal cancer; PCR‐SSCP, polymerase chain reaction‐single strand conformation polymorphism.
辐射诱发的甲状腺癌中的 p53 基因突变。
DOI：
10.1210/jcem.81.8.8768871
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Fogelfeld,L;Bauer,TK;Schneider,AB;Swartz,JE;Zitman,R
通讯作者：
Zitman,R
myc 细胞原癌基因在人甲状腺组织中的表达。
DOI：
10.1210/jcem-63-5-1170
发表时间：
1986
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Yamashita,S;Ong,J;Fagin,JA;Melmed,S
通讯作者：
Melmed,S
影响因子：
15.9
作者：
FAGIN, JA;MATSUO, K;KOEFFLER, HP
通讯作者：
KOEFFLER, HP